Publication Name	World Journal of Gastroenterology
Manuscript ID	98903
Country	China

Received	2024-08-20 00:26
Peer-Review Started	2024-07-09 02:41
To Make the First Decision
Return for Revision	2024-09-27 19:32
Revised	2024-10-06 00:31
Second Decision	2024-11-05 02:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-11-05 07:19
Articles in Press	2024-11-05 07:19
Publication Fee Transferred	2024-11-05 23:20
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-11-15 07:11
Publish the Manuscript Online	2024-11-26 07:20

ISSN	1007-9327 (print) and 2219-2840 (online)
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Category	Oncology
Manuscript Type	Basic Study
Article Title	Carnitine palmitoyltransferase-II inactivity promotes malignant progression of metabolic dysfunction-associated fatty liver disease via liver cancer stem cell activation
Manuscript Source	Unsolicited Manuscript
All Author List	Ling-Ling Wang, Yu-Ming Lu, Yi-Han Wang, Yi-Fan Wang, Rong-Fei Fang, Wen-Li Sai, Deng-Fu Yao and Min Yao
ORCID	Author(s) ORCID Number Ling-Ling Wang http://orcid.org/0009-0001-2679-422X Yu-Ming Lu http://orcid.org/0009-0009-2792-2818 Yi-Han Wang http://orcid.org/0009-0001-5719-5828 Yi-Fan Wang http://orcid.org/0009-0009-2384-7013 Rong-Fei Fang http://orcid.org/0000-0002-3255-5014 Wen-Li Sai http://orcid.org/0000-0002-9618-2720 Deng-Fu Yao http://orcid.org/0000-0002-3448-7756 Min Yao http://orcid.org/0000-0002-5473-0186
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81873915 and 81673241
Corresponding Author	Min Yao, MD, PhD, Professor, Department of Immunology, Medical School, Nantong University, No. 19 Qixiu Road, Nantong 226001, Jiangsu Province, China. erbei@ntu.edu.cn
Key Words	Metabolic dysfunction-associated fatty liver disease; Carnitine palmitoyl transferase-II; Mitochondria; T lymphocytes; Liver cancer stem cells
Core Tip	Metabolic dysfunction-associated fatty liver disease (MAFLD) is one of the main chronic liver diseases. The present study investigated the dynamic alterations in mitochondrial carnitine palmitoyl transferase-II (CPT-II) in T cells and liver cancer stem cell (LCSC) activation in MAFLD during hepatocyte malignant progression under lipid accumulation. There was a loss of mitochondrial CPT-II activity and a decrease in the MMP with decreasing numbers of CD3+ or CD4+ T cells. Mechanistically, CPT-II inactivity via the loss of innate immune function with abnormal activation of LCSCs promotes the malignant progression of MAFLD. These results suggest that CPT-II prevents lipid accumulation and LCSC activation, as well as improves IL-CD3/CD4 T cell function for hepatocellular carcinoma immunotherapy and delays MAFLD malignant progression.
Publish Date	2024-11-26 07:20
Citation	<p>Wang LL, Lu YM, Wang YH, Wang YF, Fang RF, Sai WL, Yao DF, Yao M. Carnitine palmitoyltransferase-II inactivity promotes malignant progression of metabolic dysfunction-associated fatty liver disease via liver cancer stem cell activation. <i>World J Gastroenterol</i> 2024; 30(47): 5055-5069</p>
URL	https://www.wjgnet.com/1007-9327/full/v30/i47/5055.htm
DOI	https://dx.doi.org/10.3748/wjg.v30.i47.5055

Full Article (PDF)	WJG-30-5055-with-cover.pdf
The ARRIVE Guidelines	98903-The-ARRIVE-Guidelines.pdf
Manuscript File	98903_Auto_Edited_062702.docx
Answering Reviewers	98903-answering-reviewers.pdf
Audio Core Tip	98903-audio.mp3
Biostatistics Review Certificate	98903-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	98903-conflict-of-interest-statement.pdf
Copyright License Agreement	98903-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	98903-foundation-statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	98903-institutional-animal-care-and-use-committee-statement.pdf
Institutional Review Board Approval Form or Document	98903-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	98903-non-native-speakers.pdf
Peer-review Report	98903-peer-reviews.pdf
Scientific Misconduct Check	98903-scientific-misconduct-check.png
Scientific Editor Work List	98903-scientific-editor-work-list.pdf
CrossCheck Report	98903-crosscheck-report.pdf