| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Surgery |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Local excision for middle-low rectal cancer after neoadjuvant chemoradiation: A retrospective study from a single tertiary center
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Nan Chen, Chang-Long Li, Lin Wang, Yun-Feng Yao, Yi-Fan Peng, Tian-Cheng Zhan, Jun Zhao and Ai-Wen Wu |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Beijing Municipal Administration of Hospitals Incubating Program |
PZ2020027 |
| Beijing Talent Incubating Funding |
2019-4 |
| National Natural Science Foundation of China |
81773214 |
| Beijing Hospitals Authority Clinical Medicine Development of Special Funding Support |
ZYLX202116 |
| National Key R and D Program of China |
2021YFF1201104 |
| 2019 Major and Difficult Diseases Chinese and Western Medicine Coordination Capacity Colorectal Cancer Project |
(2018)275 |
| Science Foundation of Peking University Cancer Hospital-2023 |
JC202310 |
| Natural Science Project of Chifeng City |
2023-114 |
|
| Corresponding Author |
Ai-Wen Wu, MD, PhD, Professor, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Gastrointestinal Center, Unit III, Peking University Cancer Hospital and Institute, No. 52 Fucheng Road, Haidian District, Beijing 100142, China. wuaw@sina.com |
| Key Words |
Rectal cancer; Neoadjuvant chemoradiotherapy; Local excision; Prognosis |
| Core Tip |
This retrospective study explores the safety, efficacy, and long-term prognosis of local excision (LE) in patients with middle-low rectal cancer who responded well to neoadjuvant chemoradiotherapy. The findings demonstrate that LE can achieve high rates of organ preservation and favorable oncological outcomes, including a 5-year disease-free survival rate of 88.4% and overall survival rate of 92.9%. Complications were manageable and non-severe. This study supports the potential of minimally invasive treatments in selected patients, highlighting the importance of patient participation in treatment decisions. |
| Publish Date |
2024-11-12 12:23 |
| Citation |
<p>Chen N, Li CL, Wang L, Yao YF, Peng YF, Zhan TC, Zhao J, Wu AW. Local excision for middle-low rectal cancer after neoadjuvant chemoradiation: A retrospective study from a single tertiary center. <i>World J Gastrointest Oncol</i> 2024; 16(12): 4614-4624</p> |
| URL |
https://www.wjgnet.com/1948-5204/full/v16/i12/4614.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v16.i12.4614 |
