| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Fat mass and obesity-associated protein in mesenchymal stem cells inhibits osteoclastogenesis via lnc NORAD/miR-4284 axis in ankylosing spondylitis
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Wen-Jie Liu, Jia-Xin Wang, Quan-Feng Li, Yun-Hui Zhang, Peng-Fei Ji, Jia-Hao Jin, Yi-Bin Zhang, Zi-Hao Yuan, Pei Feng, Yan-Feng Wu, Hui-Yong Shen and Peng Wang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Guangdong Provincial Clinical Research Center for Orthopedic Diseases |
2023B110001 |
| Excellent Medical Innovation Talent Program of the Eighth Affiliated Hospital of Sun Yat-sen University |
YXYXCXRC202101 |
| National Natural Science Foundation of China |
82172349, 82372372, 22105229, 32170708, 82102530 |
| National Natural Science Foundation of China |
82102541, 82103098, 82103909, 82104182, 82104350 |
| National Natural Science Foundation of China |
82170427, 82171291, 82172215, 82172385, 82302661 |
| Guangdong Natural Science Foundation |
2023A1515010568, 2021A1515111057 |
| Shenzhen Science and Technology Program |
JCYJ20220530144201004, RCBS20210609104445097 |
| Futian Healthcare Research Project |
FTWS2022022, FTWS2021013, FTWS2023072, FTWS2022047 |
|
| Corresponding Author |
Peng Wang, PhD, Department of Orthopedics, The Eighth Affiliated Hospital, Sun Yat-sen University, No. 3025 Shennan Road, Shenzhen 518033, Guangdong Province, China. wangp57@mail.sysu.edu.cn |
| Key Words |
Ankylosing spondylitis; Mesenchymal stem cells; Osteoclastogenesis; Fat mass and obesity-associated protein; Non-coding RNA activated by DNA damage |
| Core Tip |
This study explores how mesenchymal stem cells (MSCs) from ankylosing spondylitis (AS) patients inhibit osteoclastogenesis. We observed higher expression of fat mass and obesity-associated protein (FTO) in AS-MSCs compared to healthy controls. Reducing FTO expression diminished their osteoclast inhibitory effect. FTO regulates the long non-coding RNA activated by DNA damage (NORAD) by modulating its N6-methyladenosine methylation, and NORAD silencing increased osteoclast formation via miR-4284. These results highlight FTO as a key regulator of AS-MSC function and suggest the long noncoding RNA NORAD/miR-4284 axis as a novel mechanism of osteoclast inhibition in AS. |
| Publish Date |
2025-03-21 06:10 |
| Citation |
<p>Liu WJ, Wang JX, Li QF, Zhang YH, Ji PF, Jin JH, Zhang YB, Yuan ZH, Feng P, Wu YF, Shen HY, Wang P. Fat mass and obesity-associated protein in mesenchymal stem cells inhibits osteoclastogenesis via lnc NORAD/miR-4284 axis in ankylosing spondylitis. <i>World J Stem Cells</i> 2025; 17(3): 98911</p> |
| URL |
https://www.wjgnet.com/1948-0210/full/v17/i3/98911.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v17.i3.98911 |
