Publication Name	World Journal of Gastroenterology
Manuscript ID	98928
Country	China

Received	2024-08-19 07:27
Peer-Review Started	2024-07-11 08:39
To Make the First Decision
Return for Revision	2024-10-23 01:45
Revised	2024-11-05 16:56
Second Decision	2024-12-12 02:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-12-12 06:41
Articles in Press	2024-12-12 06:41
Publication Fee Transferred	2024-11-09 13:36
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-12-23 07:12
Publish the Manuscript Online	2024-12-30 09:50

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Pathology
Manuscript Type	Basic Study
Article Title	Histopathological diagnosis of microvascular invasion in hepatocellular carcinoma: Is it reliable?
Manuscript Source	Unsolicited Manuscript
All Author List	Liu-Jun Li, Chao-Qun Wu, Fei-Le Ye, Zhou Xuan, Xiao-Li Zhang, Jian-Ping Li, Jia Zhou and Zhong-Zhen Su
ORCID	Author(s) ORCID Number Zhou Xuan http://orcid.org/0000-0003-0597-8238 Zhong-Zhen Su http://orcid.org/0000-0002-7281-7357
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82072038, 82371975
Corresponding Author	Zhong-Zhen Su, MD, PhD, Department of Ultrasound, The Fifth Affiliated Hospital of Sun Yat-sen University, No. 52 Meihua Road, Zhuhai 519000, Guangdong Province, China. suzhzh3@mail.sysu.edu.cn
Key Words	Hepatocellular carcinoma; Microvascular invasion; Histopathological diagnosis; Whole-mount slide imaging; Sampling protocol
Core Tip	This study investigated the effectiveness of various pathological sampling protocols for detecting microvascular invasion (MVI) in hepatocellular carcinoma. Conventional 7-point sampling methods have a high false-negative rate for MVI detection. However, the study revealed that whole-mount slide imaging, particularly when three consecutive interval whole-mount slide imaging from the tumor center are used, significantly improves diagnostic accuracy. This innovative approach improves the detection of MVI, especially in distant nonneoplastic liver tissue that have previously been ignored, offering a more reliable method for postoperative prognosis.
Publish Date	2024-12-30 09:50
Citation	<p>Li LJ, Wu CQ, Ye FL, Xuan Z, Zhang XL, Li JP, Zhou J, Su ZZ. Histopathological diagnosis of microvascular invasion in hepatocellular carcinoma: Is it reliable? <i>World J Gastroenterol</i> 2025; 31(5): 98928</p>
URL	https://www.wjgnet.com/1007-9327/full/v31/i5/98928.htm
DOI	https://dx.doi.org/10.3748/wjg.v31.i5.98928

Full Article (PDF)	WJG-31-98928-with-cover.pdf
The ARRIVE Guidelines	98928-The-ARRIVE-Guidelines.pdf
Manuscript File	98928_Auto_Edited_013105.docx
Answering Reviewers	98928-answering-reviewers.pdf
Audio Core Tip	98928-audio.mp3
Biostatistics Review Certificate	98928-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	98928-conflict-of-interest-statement.pdf
Copyright License Agreement	98928-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	98928-foundation-statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	98928-institutional-animal-care-and-use-committee-statement.PDF
Non-Native Speakers of English Editing Certificate	98928-non-native-speakers.pdf
Peer-review Report	98928-peer-reviews.pdf
Scientific Misconduct Check	98928-scientific-misconduct-check.png
Scientific Editor Work List	98928-scientific-editor-work-list.pdf
CrossCheck Report	98928-crosscheck-report.pdf