Publication Name	World Journal of Gastroenterology
Manuscript ID	98944
Country	China

Received	2024-07-13 15:47
Peer-Review Started	2024-07-13 15:47
To Make the First Decision
Return for Revision	2024-08-13 16:21
Revised	2024-08-27 10:32
Second Decision	2024-09-04 02:37
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-09-04 06:31
Articles in Press	2024-09-04 06:31
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-09-09 06:45
Publish the Manuscript Online	2024-09-13 03:22

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Letter to the Editor
Article Title	From traditional Chinese medicine formulations to effective anticancer agents: Insights from Calculus Bovis
Manuscript Source	Invited Manuscript
All Author List	He-Tong Zhao
ORCID	Author(s) ORCID Number He-Tong Zhao http://orcid.org/0000-0003-1885-8622
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82204909
Corresponding Author	He-Tong Zhao, Doctor, MD, Doctor, Doctor, Department of Traditional Chinese Medicine, Navy No. 905 Hospital, Huashan Road, Shanghai 200050, China. zhtzhao@126.com
Key Words	Calculus Bovis; Traditional Chinese medicine; Liver cancer; Tumor microenvironment; M2 tumor-associated macrophages; Wnt/β-catenin pathway
Core Tip	This study elucidates the anticancer potential of traditional Chinese medicine (TCM), focusing on Calculus Bovis (CB), a principal component in Pien Tze Huang, in treating liver cancer. It demonstrates CB’s role in suppressing liver cancer progression by inhibiting M2 macrophage polarization through the Wnt/β-catenin pathway. Key findings emphasize the transition from holistic TCM formulations to the isolation of specific active ingredients, underscoring the necessity for modern scientific methods to dissect these components further. This approach highlights a significant shift towards integrating traditional remedies with contemporary oncological research to develop novel cancer therapies.
Publish Date	2024-09-13 03:22
Citation	<p>Zhao HT. From traditional Chinese medicine formulations to effective anticancer agents: Insights from Calculus Bovis. <i>World J Gastroenterol</i> 2024; 30(35): 4011-4013</p>
URL	https://www.wjgnet.com/1007-9327/full/v30/i35/4011.htm
DOI	https://dx.doi.org/10.3748/wjg.v30.i35.4011

Full Article (PDF)	WJG-30-4011-with-cover.pdf
Manuscript File	98944_Auto_Edited_033853.docx
Answering Reviewers	98944-answering-reviewers.pdf
Audio Core Tip	98944-audio.mp3
Conflict-of-Interest Disclosure Form	98944-conflict-of-interest-statement.pdf
Copyright License Agreement	98944-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	98944-foundation-statement.pdf
Non-Native Speakers of English Editing Certificate	98944-non-native-speakers.pdf
Peer-review Report	98944-peer-reviews.pdf
Scientific Misconduct Check	98944-scientific-misconduct-check.png
Scientific Editor Work List	98944-scientific-editor-work-list.pdf
CrossCheck Report	98944-crosscheck-report.pdf