Publication Name	World Journal of Diabetes
Manuscript ID	98948
Country	United States

Received	2024-07-10 00:33
Peer-Review Started	2024-07-10 00:33
To Make the First Decision
Return for Revision	2024-08-24 18:09
Revised	2024-08-28 16:11
Second Decision	2024-10-17 11:23
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-11-20 08:57
Articles in Press	2024-11-20 08:57
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-11-26 01:36
Publish the Manuscript Online	2024-11-30 03:48

ISSN	1948-9358 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Endocrinology & Metabolism
Manuscript Type	Minireviews
Article Title	Diabetes mellitus and glymphatic dysfunction: Roles for oxidative stress, mitochondria, circadian rhythm, artificial intelligence, and imaging
Manuscript Source	Invited Manuscript
All Author List	Kenneth Maiese
ORCID	Author(s) ORCID Number Kenneth Maiese http://orcid.org/0000-0002-5049-9116
Funding Agency and Grant Number	Funding Agency Grant Number American Diabetes Association; American Heart Association; NIH NIEHS; NIH NIA; NIH NINDS; and NIH ARRA
Corresponding Author	Kenneth Maiese, MD, National Heart, Lung, and Blood Institute, National Institutes of Health, Cellular and Molecular Signaling, Bethesda, MD 20810, United States. wntin75@yahoo.com
Key Words	Artificial intelligence; Circadian rhythm; Clock genes; Diabetes mellitus; magnetic resonance imaging; Glymphatic pathway; Mitochondria; Oxidative stress; Programmed cell death; Sleep fragmentation
Core Tip	Diabetes mellitus (DM) is a significant disorder across the globe affecting almost five hundred million individuals with significant disability that can involve musculoskeletal disease as well as cognitive loss. Multiple pathways can lead to DM that can affect the critical function of the brain’s glymphatic function, but the targeting of novel mechanisms tied to oxidative stress, mitochondrial dysfunction, circadian rhythm impairment, and new techniques such as artificial intelligence and imaging protocols offer exciting prospects for clinical care and treatment.
Publish Date	2024-11-30 03:48
Citation	<p>Maiese K. Diabetes mellitus and glymphatic dysfunction: Roles for oxidative stress, mitochondria, circadian rhythm, artificial intelligence, and imaging. <i>World J Diabetes</i> 2025; 16(1): 98948</p>
URL	https://www.wjgnet.com/1948-9358/full/v16/i1/98948.htm
DOI	https://dx.doi.org/10.4239/wjd.v16.i1.98948

Full Article (PDF)	WJD-16-98948-with-cover.pdf
Manuscript File	98948_Auto_Edited_005809.docx
Answering Reviewers	98948-answering-reviewers.pdf
Audio Core Tip	98948-audio.m4a
Conflict-of-Interest Disclosure Form	98948-conflict-of-interest-statement.pdf
Copyright License Agreement	98948-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	98948-foundation-statement.pdf
Peer-review Report	98948-peer-reviews.pdf
Scientific Misconduct Check	98948-scientific-misconduct-check.png
Scientific Editor Work List	98948-scientific-editor-work-list.pdf
CrossCheck Report	98948-crosscheck-report.pdf