Publication Name	World Journal of Hepatology
Manuscript ID	98971
Country	Malaysia

Received	2024-07-10 09:45
Peer-Review Started	2024-07-10 09:45
To Make the First Decision
Return for Revision	2024-09-18 04:03
Revised	2024-09-24 11:26
Second Decision	2024-10-11 02:34
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-10-11 08:48
Articles in Press	2024-10-11 08:48
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-10-14 03:10
Publish the Manuscript Online	2024-10-21 07:03

ISSN	1948-5182 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Letter to the Editor
Article Title	Suppression of hepatic steatosis in non-alcoholic steatohepatitis model by modified Xiaoyao San formula: Evidence, mechanisms and perspective
Manuscript Source	Invited Manuscript
All Author List	Nabil Eid, Payal Bhatnagar, Li-Li Chan and Marina Garcia-Macia
ORCID	Author(s) ORCID Number Nabil Eid http://orcid.org/0000-0002-2938-2618
Funding Agency and Grant Number
Corresponding Author	Nabil Eid, MD, PhD, Assistant Professor, Department of Anatomy, Division of Human Biology, School of Medicine, IMU University, Bukit Jalil, Kuala Lumpur 57000, Malaysia. nabilsaleheid@imu.edu.my
Key Words	Steatosis; Liver; Xiaoyao San; Inflammation; Androgen; Adenosine 5’-monophosphate-activated protein kinase; Phosphatase and tensin homolog; Autophagy; Lipophagy; Alpha smooth muscle actin
Core Tip	Modified Xiaoyao San (MXS) formula has hepato-protective effects in a male rat model of non-alcoholic steatohepatitis (NASH) via suppression of steatosis and inflammation. These protective effects are related to several mechanisms, including the regulation of sex hormone metabolism, androgen upregulation, adenosine 5’-monophosphate-activated protein kinase activation, and enhanced phosphatase and tensin homolog expression. A deeper understanding of the mechanisms behind MXS-induced reduction of hepatic steatosis could assist in the treatment of NASH and related diseases.
Publish Date	2024-10-21 07:03
Citation	<p>Eid N, Bhatnagar P, Chan LL, Garcia-Macia M. Suppression of hepatic steatosis in non-alcoholic steatohepatitis model by modified Xiaoyao San formula: Evidence, mechanisms and perspective. <i>World J Hepatol</i> 2024; 16(10): 1208-1212</p>
URL	https://www.wjgnet.com/1948-5182/full/v16/i10/1208.htm
DOI	https://dx.doi.org/10.4254/wjh.v16.i10.1208

Full Article (PDF)	WJH-16-1208-with-cover.pdf
Manuscript File	98971_Auto_Edited_014552.docx
Answering Reviewers	98971-answering-reviewers.pdf
Audio Core Tip	98971-audio.mp3
Conflict-of-Interest Disclosure Form	98971-conflict-of-interest-statement.pdf
Copyright License Agreement	98971-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate	98971-non-native-speakers.pdf
Peer-review Report	98971-peer-reviews.pdf
Scientific Misconduct Check	98971-scientific-misconduct-check.png
Scientific Editor Work List	98971-scientific-editor-work-list.pdf
CrossCheck Report	98971-crosscheck-report.png
CrossCheck Report	98971-crosscheck-report.pdf