| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
NMDAR2B/PKA/CREB signaling pathway contributes to esophageal neuropathic pain in gastroesophageal reflux disease
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yi Wang, Guan-Wu Li, Sheng-Liang Zhu, Ting-Ting Xu, Yi-Wen Qin, Chuan-Qi Cheng, Qin-Wei Zheng, Cong He, Bing-Duo Zhou and Sheng-Quan Fang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the National Major Project of Science and Technology for the Prevention and Control of the "Four Major Chronic Diseases" |
2024ZD0520903 |
| National Natural Science Foundation of China |
82004324 |
| the Training Program for High-caliber Talents of Clinical Research at Affiliated Hospitals of SHUTCM |
|
| the Training Project for Xinglin Young and Middle-Aged Talents of Shanghai University of Traditional Chinese Medicine |
SHUTCM HR (2020) 23 |
| the Project of National Famous Traditional Chinese Medicine Expert (Shengliang Zhu) Inheritance Studio |
NATCM HR (2022) 75 |
| the Zhu Shengliang Academic Experience Research Studio Project of Shanghai Famous Traditional Chinese Medicine |
SHGZS-202203 |
| the Shanghai High-Level Talent Leadership Plan for Traditional Chinese Medicine |
ZY(2021-2023)-0403 |
|
| Corresponding Author |
Bing-Duo Zhou, PhD, Department of Gastroenterology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, No. 110 Ganhe Road, Hongkou District, Shanghai 200437, China. bingduozhou@126.com |
| Key Words |
Gastroesophageal reflux disease; Esophageal hypersensitivity; N-methyl-D-aspartate; Brain-derived neurotrophic factor |
| Core Tip |
Esophageal hypersensitivity is a major contributor to refractory gastroesophageal reflux disease (GERD), meaning that minor distension and physiological acid reflux can cause significant discomfort. Given that N-methyl-D-aspartate receptors (NMDARs) may play a crucial role in visceral hypersensitivity in functional gastrointestinal disorders, this study aimed to investigate whether NMDAR2B contributes to esophageal neuropathic pain. Immunohistochemistry, Western blot, RT-PCR and ELISA were used to measure the corresponding protein and mRNA expression levels in the cingulate gyrus, dorsal thalamus, spinal dorsal horn, esophageal tissues and serum of a rat model of esophageal hypersensitivity. Our findings suggest that the NMDAR2B/ protein kinase A/cAMP-response element binding protein signaling pathway contributes to esophageal neuropathic pain in GERD patients. |
| Publish Date |
2025-03-13 10:11 |
| Citation |
<p>Wang Y, Li GW, Zhu SL, Xu TT, Qin YW, Cheng CQ, Zheng QW, He C, Zhou BD, Fang SQ. NMDAR2B/PKA/CREB signaling pathway contributes to esophageal neuropathic pain in gastroesophageal reflux disease. <i>World J Gastroenterol</i> 2025; 31(11): 98974</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i11/98974.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i11.98974 |
