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Articles Published Processes
10/22/2024 8:28:50 AM | Browse: 253 | Download: 984
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Received |
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2024-07-10 20:44 |
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Peer-Review Started |
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2024-07-10 20:44 |
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First Decision by Editorial Office Director |
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2024-08-11 17:17 |
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Return for Revision |
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2024-08-11 17:17 |
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Revised |
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2024-08-23 12:44 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2024-10-11 02:34 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2024-10-11 09:30 |
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Articles in Press |
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2024-10-11 09:30 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2024-10-16 08:07 |
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Publish the Manuscript Online |
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2024-10-22 08:28 |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Germline pathogenic variants among high hereditary risk patients with breast and ovarian cancer and unaffected subjects in Lebanese Arab women
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hiba A Moukadem, Mohammad A Fakhreddine, Nada Assaf, Nadine Safi, Ahmad Al Masry, Monita Al Darazi, Rami Mahfouz and Nagi S El Saghir |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Nagi S El Saghir, MD, Professor, Division of Hematology/Oncology, Department of Internal Medicine, American University of Beirut Medical Center, Cairo Street, PO Box 11-0236, Riad El Solh, Beirut 1107 2020, Lebanon. ns23@aub.edu.lb |
| Key Words |
Breast cancer; Ovarian cancer; Breast cancer susceptibility gene 1/2; Germline pathogenic variant; High hereditary risk |
| Core Tip |
This is the first study on referred patients with breast and/or ovarian cancer and subjects at high hereditary risk for germline pathogenic variant testing among ethnic Lebanese Arab women. The prevalence of pathogenic variants was 8.63% in patients with breast cancer and 15.1% in patients with ovarian cancer. Among the relatives of patients with breast cancer susceptibility gene (BRCA) 1/2 pathogenic variants, 31% tested positive for the same variant, while 5.3% of subjects who tested positive due to a family history of breast cancer had a BRCA pathogenic variant. The results of this study support the hypothesis that the c.131G > T nucleotide change is a founder pathogenic variant in this population. |
| Publish Date |
2024-10-22 08:28 |
| Citation |
Moukadem HA, Fakhreddine MA, Assaf N, Safi N, Al Masry A, Al Darazi M, Mahfouz R, El Saghir NS. Germline pathogenic variants among high hereditary risk patients with breast and ovarian cancer and unaffected subjects in Lebanese Arab women. World J Clin Oncol 2024; 15(12): 1481-1490
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| URL |
https://www.wjgnet.com/2218-4333/full/v15/i12/1481.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v15.i12.1481 |
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