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Publication Name World Journal of Hepatology
Manuscript ID 9902
Country/Territory India
Received
2014-03-03 16:56
Peer-Review Started
2014-03-03 20:18
To Make the First Decision
2014-03-26 15:25
Return for Revision
2014-04-16 09:04
Revised
2014-04-29 00:00
Second Decision
2014-05-29 08:56
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-05-29 09:46
Articles in Press
2014-05-29 11:57
Publication Fee Transferred
Edit the Manuscript by Language Editor
2014-06-17 11:21
Typeset the Manuscript
2014-08-28 14:02
Publish the Manuscript Online
2014-08-29 07:54
ISSN 1948-5182 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Biochemistry & Molecular Biology
Manuscript Type Review
Article Title Role of adipokines and peroxisome proliferator-activated receptors in nonalcoholic fatty liver disease
Manuscript Source Unsolicited Manuscript
All Author List Vettickattuparambil George Giby and Thekkuttuparambil Ananthanarayanan Ajith
Funding Agency and Grant Number
Corresponding Author Thekkuttuparambil Ananthanarayanan Ajith, PhD, Professor Biochemistry, Department of Biochemistry, Amala Institute of Medical Sciences, Amala Nagar, Thrissur-680 555, Kerala, India. taajith@rediffmail.com
Key Words Nonalcoholic fatty liver disease; Adipose tissue; Energy homeostasis; Peroxisome proliferator-activated receptors; Adipokines
Core Tip Nonalcoholic fatty liver disease (NAFLD) is one of the principal causes for chronic liver disease. Recent reports suggested a positive association between cytokines secreted by the adipocytes, such as tumor necrosis factor-α, transforming growth factor-β, and interleukin (IL)-6 in NAFLD. Furthermore, hepatic natural killer T-cells produce IL-13 and IL-4; IL-13 may then activate hepatic stellate cells to produce pro-inflammatory cytokines and initiate oxidative stress, iron overload and fibrosis. Downregulation of peroxisome proliferator-activated receptors (PPAR), particularly PPAR-α in cases of hepatic steatosis, may facilitate the activity of hepatic proinflammatory cytokines. Hence, PPAR-γ and PPAR-α ligands have been considered for administration to prevent the initial inflammatory reactions and render protection to the liver cells.
Publish Date 2014-08-29 07:54
Citation Giby VG, Ajith TA. Role of adipokines and peroxisome proliferator-activated receptors in nonalcoholic fatty liver disease. World J Hepatol 2014; 6(8): 570-579
URL http://www.wjgnet.com/1948-5182/full/v6/i8/570.htm
DOI http://dx.doi.org/10.4254/wjh.v6.i8.570
Full Article (PDF) WJH-6-570.pdf
Full Article (Word) WJH-6-570.doc
Manuscript File 9902-Review.doc
Answering Reviewers 9902-Answering reviewers.pdf
Copyright License Agreement 9902-Copyright assignment.pdf
Institutional Review Board Approval Form or Document Ethics_Committee_20140303111121.jpg
Non-Native Speakers of English Editing Certificate Editing_Certificate_20140303111225.jpg
Peer-review Report 9902-Peer review(s).pdf
Scientific Misconduct Check 9902-CrossCheck.jpg
Scientific Editor Work List 9902-Scientific editor work list.pdf