Publication Name	World Journal of Hepatology
Manuscript ID	9902
Country	India

Received	2014-03-03 16:56
Peer-Review Started	2014-03-03 20:18
To Make the First Decision	2014-03-26 15:25
Return for Revision	2014-04-16 09:04
Revised	2014-04-29 00:00
Second Decision	2014-05-29 08:56
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-05-29 09:46
Articles in Press	2014-05-29 11:57
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-06-17 11:21
Typeset the Manuscript	2014-08-28 14:02
Publish the Manuscript Online	2014-08-29 07:54

ISSN	1948-5182 (online)
Open Access
Copyright
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Website	http://www.wjgnet.com

Category	Biochemistry & Molecular Biology
Manuscript Type	Review
Article Title	Role of adipokines and peroxisome proliferator-activated receptors in nonalcoholic fatty liver disease
Manuscript Source	Unsolicited Manuscript
All Author List	Vettickattuparambil George Giby and Thekkuttuparambil Ananthanarayanan Ajith
Funding Agency and Grant Number
Corresponding Author	Thekkuttuparambil Ananthanarayanan Ajith, PhD, Professor Biochemistry, Department of Biochemistry, Amala Institute of Medical Sciences, Amala Nagar, Thrissur-680 555, Kerala, India. taajith@rediffmail.com
Key Words	Nonalcoholic fatty liver disease; Adipose tissue; Energy homeostasis; Peroxisome proliferator-activated receptors; Adipokines
Core Tip	Nonalcoholic fatty liver disease (NAFLD) is one of the principal causes for chronic liver disease. Recent reports suggested a positive association between cytokines secreted by the adipocytes, such as tumor necrosis factor-α, transforming growth factor-β, and interleukin (IL)-6 in NAFLD. Furthermore, hepatic natural killer T-cells produce IL-13 and IL-4; IL-13 may then activate hepatic stellate cells to produce pro-inflammatory cytokines and initiate oxidative stress, iron overload and fibrosis. Downregulation of peroxisome proliferator-activated receptors (PPAR), particularly PPAR-α in cases of hepatic steatosis, may facilitate the activity of hepatic proinflammatory cytokines. Hence, PPAR-γ and PPAR-α ligands have been considered for administration to prevent the initial inflammatory reactions and render protection to the liver cells.
Publish Date	2014-08-29 07:54
Citation	Giby VG, Ajith TA. Role of adipokines and peroxisome proliferator-activated receptors in nonalcoholic fatty liver disease. World J Hepatol 2014; 6(8): 570-579
URL	http://www.wjgnet.com/1948-5182/full/v6/i8/570.htm
DOI	http://dx.doi.org/10.4254/wjh.v6.i8.570

Full Article (PDF)	WJH-6-570.pdf
Full Article (Word)	WJH-6-570.doc
Manuscript File	9902-Review.doc
Answering Reviewers	9902-Answering reviewers.pdf
Copyright License Agreement	9902-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	Ethics_Committee_20140303111121.jpg
Non-Native Speakers of English Editing Certificate	Editing_Certificate_20140303111225.jpg
Peer-review Report	9902-Peer review(s).pdf
Scientific Misconduct Check	9902-CrossCheck.jpg
Scientific Editor Work List	9902-Scientific editor work list.pdf