| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Radiology, Nuclear Medicine & Medical Imaging |
| Manuscript Type |
Retrospective Study |
| Article Title |
Beyond the tumor region: Peritumoral radiomics enhances prognostic accuracy in locally advanced rectal cancer
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zhi-Ying Liang, Mao-Li Yu, Hui Yang, Hao-Jiang Li, Hui Xie, Chun-Yan Cui, Wei-Jing Zhang, Chao Luo, Pei-Qiang Cai, Xiao-Feng Lin, Kun-Feng Liu, Lang Xiong, Li-Zhi Liu and Bi-Yun Chen |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Bi-Yun Chen, PhD, Department of Radiology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, No. 651 Dongfeng Dong Road, Guangzhou 510060, Guangdong Province, China. chenby2@sysucc.org.cn |
| Key Words |
Rectal cancer; Peritumoral radiomics; Intratumoral radiomics; Prognosis analysis; Variable importance analysis; Tumor microenvironment |
| Core Tip |
This study highlights the superior prognostic value of peritumoral radiomics over intratumoral radiomics in predicting progression-free survival in patients with locally advanced rectal cancer. By integrating peritumoral, intratumoral, and clinicopathological features, our comprehensive model achieved high predictive accuracy, significantly improving risk stratification for disease progression. Notably, peritumoral features emerged as the most influential predictors of progression-free survival among the features analyzed. These findings underscore the importance of focusing on peritumoral radiomic characteristics in prognostic assessments. Additionally, we developed a nomogram incorporating these features to facilitate personalized treatment strategies and clinical decision-making in locally advanced rectal cancer. |
| Publish Date |
2025-01-23 05:47 |
| Citation |
<p>Liang ZY, Yu ML, Yang H, Li HJ, Xie H, Cui CY, Zhang WJ, Luo C, Cai PQ, Lin XF, Liu KF, Xiong L, Liu LZ, Chen BY. Beyond the tumor region: Peritumoral radiomics enhances prognostic accuracy in locally advanced rectal cancer. <i>World J Gastroenterol</i> 2025; 31(8): 99036</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i8/99036.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i8.99036 |
