| ISSN |
2220-315x (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Surgery |
| Manuscript Type |
Basic Study |
| Article Title |
Platelet rich plasma, adipose tissue micrografts, and regenerative mimetic factors for abdominal wall defect reconstruction: Experimental study protocol
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Konstantinos Zapsalis, Orestis Ioannidis, Christos Xylas, Konstantinos Siozos, Georgios Gemousakakis, Elissavet Anestiadou, Savvas Symeonidis, Stefanos Bitsianis, Efstathios Kotidis, Angeliki Cheva, Chryssa Bekiari, Antonia Loukousia, Konstantinos Angelopoulos, Manousos-Georgios Pramateftakis, Ioannis Mantzoros, Freiderikos Tserkezidis, Barbara Driagka and Stamatios Angelopoulos |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Konstantinos Zapsalis, MD, Fourth Department of Surgery, Medical School, Aristotle University of Thessaloniki, Konstantinoupoleos 49, Thessaloniki 57010, Kentrikí Makedonía, Greece. konstzapsalis@yahoo.gr |
| Key Words |
Incisional hernia; Regenerative agents; Platelet rich plasma; Adipose τissue μicrografts; Regenerative mimetic factors; Acellular collagen–elastin matrix; Polyglactin mesh; Abdominal wall defects; Laparotomy |
| Core Tip |
This study protocol explores innovative regenerative strategies for abdominal wall defect repair using a combination of platelet rich plasma, adipose tissue micrografts, and regenerative glycosaminoglycan mimetics (ReGeneraTing Agent). By leveraging their unique properties in promoting cell proliferation and enhancing extracellular matrix repair, these agents are introduced into denervated tissue following a controlled abdominal wall excision in rats. Coupled with collagen-elastin matrices and absorbable polyglactin mesh, this approach aims to improve tissue healing, minimize complications, and reduce the burden of incisional hernias, offering an alternative to current mesh-based interventions. |
| Publish Date |
2025-04-16 05:36 |
| Citation |
<p>Zapsalis K, Ioannidis O, Xylas C, Siozos K, Gemousakakis G, Anestiadou E, Symeonidis S, Bitsianis S, Kotidis E, Cheva A, Bekiari C, Loukousia A, Angelopoulos K, Pramateftakis MG, Mantzoros I, Tserkezidis F, Driagka B, Angelopoulos S. Platelet rich plasma, adipose tissue micrografts, and regenerative mimetic factors for abdominal wall defect reconstruction: Experimental study protocol. <i>World J Exp Med</i> 2025; 15(2): 99065</p> |
| URL |
https://www.wjgnet.com/2220-315x/full/v15/i2/99065.htm |
| DOI |
https://dx.doi.org/10.5493/wjem.v15.i2.99065 |
