Publication Name	World Journal of Gastroenterology
Manuscript ID	9908
Country	Norway

Received	2014-03-03 21:45
Peer-Review Started	2014-03-14 09:49
To Make the First Decision	2014-04-15 19:34
Return for Revision	2014-04-21 19:51
Revised	2014-05-05 12:54
Second Decision	2014-06-23 10:08
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-06-23 10:16
Articles in Press	2014-06-23 10:32
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-11-11 11:53
Publish the Manuscript Online	2014-11-20 20:51

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Effect of liver regeneration on malignant hepatic tumors
Manuscript Source	Invited Manuscript
All Author List	Ji-Hua Shi and Pål-Dag Line
Funding Agency and Grant Number
Corresponding Author	P?l-Dag Line, MD PhD FEBS (Tx), Chairman, Department of Transplantation Medicine, Oslo University Hospital, Postboks 4950 Nydalen – 0424, Oslo, Norway E-mail: p.d.line@medisin.uio.no Tel: +47 23070509 Fax: +47 23070510
Key Words	Hepatocellular carcinoma; Colorectal cancer; Recurrence; Liver regeneration; Hepatic progenitor cell; Epithelial to mesenchymal transition
Core Tip	The liver has a unique capacity for regeneration after cellular damage or partial removal of tissue,and modern liver surgery relies on this property. Liver regeneration is a complex process involving a large array of growth factors, cytokines and cells to restore hepatic mass and function. Experimental and clinical data indicate that the regeneration signals facilitate the growth of both primary and secondary liver tumors and can alter their malignant potential. This is an important mechanism underlying recurrence after liver surgery. New therapeutic strategies founded on better insight into the relationship between liver regeneration and tumor biology are needed.
Publish Date	2014-11-20 20:51
Citation	Shi JH, Line PD. Effect of liver regeneration on malignant hepatic tumors. World J Gastroenterol 2014; 20(43): 16167-16177
URL	http://www.wjgnet.com/1007-9327/full/v20/i43/16167.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i43.16167

Full Article (PDF)	WJG-20-16167.pdf
Full Article (Word)	WJG-20-16167.doc
Manuscript File	9908-Review.docx
Answering Reviewers	9908-Answering reviewers.pdf
Copyright License Agreement	9908-Copyright assignment.pdf
Peer-review Report	9908-Peer review.pdf
Scientific Misconduct Check	9908-CorssCheck.jpg
Scientific Editor Work List	9908-Scientific editor work list.pdf