Publication Name	World Journal of Gastroenterology
Manuscript ID	99136
Country	China

Received	2024-07-14 18:59
Peer-Review Started	2024-07-14 18:59
To Make the First Decision
Return for Revision	2024-08-09 22:00
Revised	2024-08-22 16:19
Second Decision	2024-09-05 02:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-09-05 06:38
Articles in Press	2024-09-05 06:38
Publication Fee Transferred	2024-09-06 11:10
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-09-14 05:12
Publish the Manuscript Online	2024-09-20 08:50

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Basic Study
Article Title	Construction and validation of a pancreatic cancer prognostic model based on genes related to the hypoxic tumor microenvironment
Manuscript Source	Unsolicited Manuscript
All Author List	Fan Yang, Na Jiang, Xiao-Yu Li, Xing-Si Qi, Zi-Bin Tian and Ying-Jie Guo
ORCID	Author(s) ORCID Number Xiao-Yu Li http://orcid.org/0000-0001-8017-207X Zi-Bin Tian http://orcid.org/0000-0002-3211-2934 Ying-Jie Guo http://orcid.org/0000-0003-2909-9887
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82100581
Corresponding Author	Ying-Jie Guo, MD, Doctor, Doctor, Department of Gastroenterology, The Affiliated Hospital of Qingdao University, No. 16 Jiangsu Road, Qingdao 266000, Shandong, China. guoyingjie305@163.com
Key Words	Pancreatic cancer; Hypoxia; Prognostic model; Immune microenvironment; Plasminogen activator urokinase
Core Tip	In this study, a prognostic model based on the expression levels of the hypoxia-related genes CAPN2, PLAU, and CCNA2 was developed for pancreatic cancer. Compared with traditional methods, the model demonstrated superior predictive accuracy, and the model risk score was strongly correlated with clinical features such as cancer stage and tumor size. The risk score was also significantly associated with chemotherapy drug sensitivity and metabolic pathway activity. These findings highlight the model's potential to enhance personalized treatment selection and improve prognosis.
Publish Date	2024-09-20 08:50
Citation	<p>Yang F, Jiang N, Li XY, Qi XS, Tian ZB, Guo YJ. Construction and validation of a pancreatic cancer prognostic model based on genes related to the hypoxic tumor microenvironment. <i>World J Gastroenterol</i> 2024; 30(36): 4057-4070</p>
URL	https://www.wjgnet.com/1007-9327/full/v30/i36/4057.htm
DOI	https://dx.doi.org/10.3748/wjg.v30.i36.4057

Full Article (PDF)	WJG-30-4057-with-cover.pdf
Manuscript File	99136_Auto_Edited_010920.docx
Answering Reviewers	99136-answering-reviewers.pdf
Audio Core Tip	99136-audio.mp3
Biostatistics Review Certificate	99136-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	99136-conflict-of-interest-statement.pdf
Copyright License Agreement	99136-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	99136-foundation-statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	99136-institutional-animal-care-and-use-committee-statement.pdf
Institutional Review Board Approval Form or Document	99136-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	99136-non-native-speakers.pdf
Supplementary Material	99136-supplementary-material.pdf
Peer-review Report	99136-peer-reviews.pdf
Scientific Misconduct Check	99136-scientific-misconduct-check.png
Scientific Editor Work List	99136-scientific-editor-work-list.pdf
CrossCheck Report	99136-crosscheck-report.pdf