Publication Name	World Journal of Diabetes
Manuscript ID	99142
Country	United States

Received	2024-07-14 19:19
Peer-Review Started	2024-07-14 19:19
To Make the First Decision
Return for Revision	2024-11-06 08:34
Revised	2024-11-30 16:35
Second Decision	2025-01-02 02:36
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-01-02 06:07
Articles in Press	2025-01-02 06:07
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-01-10 02:34
Publish the Manuscript Online	2025-01-21 09:26

ISSN	1948-9358 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Endocrinology & Metabolism
Manuscript Type	Letter to the Editor
Article Title	Investigating the impact of intestinal glucagon-like peptide-1 on hypoglycemia in type 1 diabetes
Manuscript Source	Invited Manuscript
All Author List	Mahmoud Nassar, Angad Singh Gill and Erlin Marte
ORCID	Author(s) ORCID Number Mahmoud Nassar http://orcid.org/0000-0002-5401-9562
Funding Agency and Grant Number
Corresponding Author	Mahmoud Nassar, MD, PhD, Department of Internal Medicine, Division of Endocrinology, Diabetes and Metabolism, Jacobs School of Medicine and Biomedical Sciences, University of Buffalo, 705 Maple Road, Buffalo, NY 14221, United States. dr.nassar@aucegypt.edu
Key Words	Type 1 diabetes mellitus; Intestinal glucagon-like peptide-1; Hypoglycemia management; Hormonal counter-regulation; Diabetic mice model
Core Tip	This study unveils a novel role of intestinal glucagon-like peptide-1 (GLP-1) in type 1 diabetes (T1D) hypoglycemia management. It reveals that increased GLP-1 and GLP-1 receptor expression in the intestine correlates with reduced adrenal and glucagon responses, which are crucial for glucose stabilization during hypoglycemic episodes. These findings suggest a significant modulation of hormonal counter-regulation pathways by intestinal GLP-1, pointing towards new therapeutic approaches that could better manage hypoglycemia in T1D without compromising natural counterregulatory mechanisms.
Publish Date	2025-01-21 09:26
Citation	<p>Nassar M, Gill AS, Marte E. Investigating the impact of intestinal glucagon-like peptide-1 on hypoglycemia in type 1 diabetes. <i>World J Diabetes</i> 2025; 16(3): 99142</p>
URL	https://www.wjgnet.com/1948-9358/full/v16/i3/99142.htm
DOI	https://dx.doi.org/10.4239/wjd.v16.i3.99142

Full Article (PDF)	WJD-16-99142-with-cover.pdf
Manuscript File	99142_Auto_Edited_080758.docx
Answering Reviewers	99142-answering-reviewers.pdf
Audio Core Tip	99142-audio.m4a
Conflict-of-Interest Disclosure Form	99142-conflict-of-interest-statement.pdf
Copyright License Agreement	99142-copyright-assignment.pdf
Supplementary Material	99142-supplementary-material.pdf
Peer-review Report	99142-peer-reviews.pdf
Scientific Misconduct Check	99142-scientific-misconduct-check.png
Scientific Editor Work List	99142-scientific-editor-work-list.pdf
CrossCheck Report	99142-crosscheck-report.png
CrossCheck Report	99142-crosscheck-report.pdf