| ISSN |
2220-3230 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Surgery |
| Manuscript Type |
Retrospective Study |
| Article Title |
Upper limit of normothermic machine preservation of liver grafts from donation after circulatory death yet to be defined
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
William H Archie, Maria Baimas-George, Nathanael Haynes, Souma Kundu, Katheryn Peterson, Chase J Wehrle, Damien Huckleberry, Lon Eskind, David Levi, Jose R Soto, Roger Denny, Vincent Casingal, Allyson Cochran, Erin H Rein and Dionisios Vrochides |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
William H Archie, MD, Division of Adominal Transplant, Department of Surgery, Carolinas Medical Center, 1000 Blythe Blvd, Charlotte, NC 28203, United States. william.archie@atriumhealth.org |
| Key Words |
Normothermic machine pump perfusion; Liver transplant; Donation after circulatory death; Ex-vivo perfusion; Ischemic cholangiopathy |
| Core Tip |
We performed a retrospective study of the first 50 liver transplants at a single-center tertiary institution to determine if there was any observed relationship between machine perfusion time (MPT) and post-transplant graft function for liver grafts from donation after circulatory death (DCD) and found there to be none despite MPT ranging from six up to 24 hours. This leads us to conclude that the pump itself, not duration, provides the benefit to the graft and that we have yet to determine the upper time limit for maintaining DCD livers on pump, if one exists. |
| Publish Date |
2025-02-21 10:12 |
| Citation |
<p>Archie WH, Baimas-George M, Haynes N, Kundu S, Peterson K, Wehrle CJ, Huckleberry D, Eskind L, Levi D, Soto JR, Denny R, Casingal V, Cochran A, Rein EH, Vrochides D. Upper limit of normothermic machine preservation of liver grafts from donation after circulatory death yet to be defined. <i>World J Transplant</i> 2025; 15(2): 99170</p> |
| URL |
https://www.wjgnet.com/2220-3230/full/v15/i2/99170.htm |
| DOI |
https://dx.doi.org/10.5500/wjt.v15.i2.99170 |
