Publication Name	World Journal of Methodology
Manuscript ID	99176
Country	Italy

Received	2024-08-22 08:48
Peer-Review Started	2024-07-15 16:55
To Make the First Decision
Return for Revision	2024-12-05 07:04
Revised	2025-01-03 07:39
Second Decision	2025-02-07 02:38
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-02-08 03:18
Articles in Press	2025-02-08 03:18
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-02-14 02:39
Publish the Manuscript Online	2025-03-06 10:23

ISSN	2222-0682 (online)
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Category	Dentistry, Oral Surgery & Medicine
Manuscript Type	Editorial
Article Title	Interleukin 10 supplement to reduce episodes of recurrent aphthous stomatitis
Manuscript Source	Invited Manuscript
All Author List	Cinzia Casu, Angelo Michele Inchingolo and Germano Orrù
ORCID	Author(s) ORCID Number Cinzia Casu http://orcid.org/0000-0002-7962-2712
Funding Agency and Grant Number
Corresponding Author	Cinzia Casu, PhD, Department of Surgical Science, Oral Biotechnology Laboratory, University of Cagliari, Via ospedale 54, Cagliari 09124, Italy. ginzia.85@hotmail.it
Key Words	Recurrent aphthous stomatitis; Interleukin 10; Low-dose medicine; Aphthosis; Interleukin
Core Tip	Aphthous lesions and recurrent aphthous stomatitis are among the most common oral diseases and are often very painful. In some patients, the frequency of new onset is greater than once a month. The pathogenetic mechanism involves high levels of interleukin (IL)-1 and IL-6 and low levels of IL-10. Although several aids that are able to reduce healing times and pain have been proposed in the scientific literature, there is still no treatment that drastically reduces the frequency of lesion onset. Supplements based on IL-10, administered at low doses for prolonged periods, referred to as low-dose medicine, could be effective in reducing relapses.
Publish Date	2025-03-06 10:23
Citation	<p>Casu C, Inchingolo AM, Orrù G. Interleukin 10 supplement to reduce episodes of recurrent aphthous stomatitis. <i>World J Methodol</i> 2025; 15(3): 99176</p>
URL	https://www.wjgnet.com/2222-0682/full/v15/i3/99176.htm
DOI	https://dx.doi.org/10.5662/wjm.v15.i3.99176

Full Article (PDF)	WJM-15-99176-with-cover.pdf
Manuscript File	99176_Auto_Edited_055824.docx
Answering Reviewers	99176-answering-reviewers.pdf
Audio Core Tip	99176-audio.ogg
Conflict-of-Interest Disclosure Form	99176-conflict-of-interest-statement.pdf
Copyright License Agreement	99176-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate	99176-non-native-speakers.pdf
Peer-review Report	99176-peer-reviews.pdf
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Scientific Editor Work List	99176-scientific-editor-work-list.pdf
CrossCheck Report	99176-crosscheck-report.pdf