Publication Name	World Journal of Orthopedics
Manuscript ID	99187
Country	India

Received	2024-07-16 04:13
Peer-Review Started	2024-07-16 04:13
To Make the First Decision
Return for Revision	2024-08-12 06:31
Revised	2024-08-31 04:25
Second Decision	2024-09-11 02:43
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-09-11 11:05
Articles in Press	2024-09-11 11:05
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-09-19 13:03
Publish the Manuscript Online	2024-10-11 07:40

ISSN	2218-5836 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Orthopedics
Manuscript Type	Editorial
Article Title	Evidence-based orthobiologic practice: Current evidence review and future directions
Manuscript Source	Invited Manuscript
All Author List	Madhan Jeyaraman, Naveen Jeyaraman, Swaminathan Ramasubramanian, Sangeetha Balaji and Sathish Muthu
ORCID	Author(s) ORCID Number Madhan Jeyaraman http://orcid.org/0000-0002-9045-9493 Naveen Jeyaraman http://orcid.org/0000-0002-4362-3326 Swaminathan Ramasubramanian http://orcid.org/0000-0001-8845-8427 Sangeetha Balaji http://orcid.org/0000-0002-1566-1333 Sathish Muthu http://orcid.org/0000-0002-7143-4354
Funding Agency and Grant Number
Corresponding Author	Madhan Jeyaraman, MS, PhD, Assistant Professor, Research Associate, Department of Orthopaedics, ACS Medical College and Hospital, Dr MGR Educational and Research Institute, Velappanchavadi, Chennai 600077, Tamil Nadu, India. madhanjeyaraman@gmail.com
Key Words	Orthobiologics; Platelet-rich plasma; Stem cells; Musculoskeletal regeneration; Regenerative medicine; Evidence-based medicine
Core Tip	Orthobiologics, including platelet-rich plasma, mesenchymal stem cells, bone marrow aspirate concentrate, stromal vascular fraction, and autologous chondrocyte implantation, show significant potential in enhancing musculoskeletal healing and reducing the need for invasive surgeries. Despite their growing popularity, inconsistencies in treatment protocols and evidence levels highlight the need for standardized, high-quality research. Future advancements in delivery systems, personalized medicine, and novel cell sources may further optimize their efficacy and safety.
Publish Date	2024-10-11 07:40
Citation	<p>Jeyaraman M, Jeyaraman N, Ramasubramanian S, Balaji S, Muthu S. Evidence-based orthobiologic practice: Current evidence review and future directions. <i>World J Orthop</i> 2024; 15(10): 908-917</p>
URL	https://www.wjgnet.com/2218-5836/full/v15/i10/908.htm
DOI	https://dx.doi.org/10.5312/wjo.v15.i10.908

Full Article (PDF)	WJO-15-908-with-cover.pdf
Manuscript File	99187_Auto_Edited_033642.docx
Answering Reviewers	99187-answering-reviewers.pdf
Audio Core Tip	99187-audio.opus
Conflict-of-Interest Disclosure Form	99187-conflict-of-interest-statement.pdf
Copyright License Agreement	99187-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate	99187-non-native-speakers.pdf
Peer-review Report	99187-peer-reviews.pdf
Scientific Misconduct Check	99187-scientific-misconduct-check.png
Scientific Editor Work List	99187-scientific-editor-work-list.pdf
CrossCheck Report	99187-crosscheck-report.pdf