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Articles Published Processes
10/31/2024 7:40:50 AM | Browse: 88 | Download: 418
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Received |
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2024-07-18 14:48 |
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Peer-Review Started |
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2024-07-18 14:48 |
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First Decision by Editorial Office Director |
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2024-08-15 07:17 |
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Return for Revision |
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2024-08-15 07:17 |
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Revised |
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2024-08-22 02:13 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2024-08-27 02:42 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2024-08-27 13:04 |
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Articles in Press |
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2024-08-27 13:04 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2024-09-19 08:05 |
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Publish the Manuscript Online |
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2024-10-31 07:40 |
| ISSN |
2220-315x (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Minireviews |
| Article Title |
Melanocortin 4 receptor mutation in obesity
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Gumpeny R Sridhar and Lakshmi Gumpeny |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Gumpeny R Sridhar, FRCP (Hon), Adjunct Professor, Department of Endocrinology and Diabetes, Endocrine and Diabetes Centre, 15-12-15 Krishnanagar, Visakhapatnam 530002, Andhra Pradesh, India. sridharvizag@gmail.com |
| Key Words |
Leptin-melanocortin pathway; Downstream; G protein; Cyclic AMP; Mutation; Obesity syndromes; Screening; Setmelanotide |
| Core Tip |
The leptin-melanocortin pathway regulates energy balance and body weight. Melanocortin-4 receptor (MC4R) plays a key role in this pathway by reducing hunger, inducing satiety and increasing energy expenditure. Mutations of MC4R result in obesity and hyperphagia in childhood. Setmelanotide is an MC4R agonist approved for use in obesity caused by leptin-melanocortin pathway dysfunction. |
| Publish Date |
2024-10-31 07:40 |
| Citation |
Sridhar GR, Gumpeny L. Melanocortin 4 receptor mutation in obesity. World J Exp Med 2024; 14(4): 99239 |
| URL |
https://www.wjgnet.com/2220-315x/full/v14/i4/99239.htm |
| DOI |
https://dx.doi.org/10.5493/wjem.v14.i4.99239 |
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