Publication Name	World Journal of Gastroenterology
Manuscript ID	99247
Country	Canada

Received	2024-08-20 01:04
Peer-Review Started	2024-07-17 23:52
To Make the First Decision
Return for Revision	2024-09-15 21:09
Revised	2024-09-26 20:28
Second Decision	2024-10-09 02:39
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-10-09 06:25
Articles in Press	2024-10-09 06:25
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-10-16 02:53
Publish the Manuscript Online	2024-10-31 10:39

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Letter to the Editor
Article Title	Metabolic dysfunction–associated steatotic liver disease: The question of long-term high-normal alanine aminotransferase as a screening test
Manuscript Source	Invited Manuscript
All Author List	Terence N Moyana
ORCID	Author(s) ORCID Number Terence N Moyana http://orcid.org/0009-0006-8426-8638
Funding Agency and Grant Number
Corresponding Author	Terence N Moyana, MD, Department of Pathology and Laboratory Medicine, University of Ottawa and The Ottawa Hospital, 501 Smyth Road, General Campus, Ottawa K1H 8L6, Ontario, Canada. tmoyana@eorla.ca
Key Words	Predictive models; Biomarkers; Upper limit of normal; Screening; Pathophysiology; Alanine aminotransferase; Metabolic dysfunction–associated steatotic liver disease
Core Tip	High normal alanine aminotransferase (ALT) has potential utility in screening for new-onset metabolic dysfunction-associated steatotic liver disease (MASLD). In view of its biochemistry, the upper limit of normal for ALT has to be interpreted with caution since it can be influenced by various methodologic and physiologic factors. Its utility as a screening tool could be enhanced by combining it with other serum biomarkers, cardiometabolic risk factors, imaging techniques and MASLD genetics to create predictive nomograms or machine learning classifiers.
Publish Date	2024-10-31 10:39
Citation	<p>Moyana TN. Metabolic dysfunction–associated steatotic liver disease: The question of long-term high-normal alanine aminotransferase as a screening test. <i>World J Gastroenterol</i> 2024; 30(42): 4576-4582</p>
URL	https://www.wjgnet.com/1007-9327/full/v30/i42/4576.htm
DOI	https://dx.doi.org/10.3748/wjg.v30.i42.4576

Full Article (PDF)	WJG-30-4576-with-cover.pdf
Manuscript File	99247_Auto_Edited_073220.docx
Answering Reviewers	99247-answering-reviewers.pdf
Audio Core Tip	99247-audio.m4a
Conflict-of-Interest Disclosure Form	99247-conflict-of-interest-statement.pdf
Copyright License Agreement	99247-copyright-assignment.pdf
Peer-review Report	99247-peer-reviews.pdf
Scientific Misconduct Check	99247-scientific-misconduct-check.png
Scientific Editor Work List	99247-scientific-editor-work-list.pdf
CrossCheck Report	99247-crosscheck-report.png
CrossCheck Report	99247-crosscheck-report.pdf