Publication Name	World Journal of Hepatology
Manuscript ID	99292
Country	China

Received	2024-08-21 05:53
Peer-Review Started	2024-07-19 01:37
To Make the First Decision
Return for Revision	2024-11-26 01:10
Revised	2024-12-05 04:52
Second Decision	2025-01-18 02:46
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-01-18 07:41
Articles in Press	2025-01-18 07:41
Publication Fee Transferred	2024-12-11 03:26
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-02-11 00:57
Publish the Manuscript Online	2025-02-20 08:39

ISSN	1948-5182 (online)
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Category	Infectious Diseases
Manuscript Type	Basic Study
Article Title	Hepatitis B virus confers innate immunity evasion through hepatitis B virus-miR-3 down-regulation of cGAS-Sting-IFN signaling
Manuscript Source	Unsolicited Manuscript
All Author List	Zhen-Yu Xu, Jia-Shi Gao, Ying He, Xin-Qiang Xiao, Guo-Zhong Gong and Min Zhang
ORCID	Author(s) ORCID Number Zhen-Yu Xu http://orcid.org/0000-0002-5839-5741 Guo-Zhong Gong http://orcid.org/0000-0002-1824-1625 Min Zhang http://orcid.org/0000-0002-2363-0393
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China, Key Project 82430071 The Scientific Research Program of FuRong Laboratory 2023SK2108 Clinical Medical Research Center for Viral Hepatitis of Hunan Province 2023SK4009 Hunan Provincial Natural Science Foundation 2023JJ60440 Hunan Provincial Health Commission Research Program C202303088786
Corresponding Author	Guo-Zhong Gong, MD, Department of Infectious Disease, The Second Xiangya Hospital, Central South University, No. 139 Renmin Middle Road, Changsha 410011, Hunan Province, China. gongguozhong@csu.edu.cn
Key Words	Hepatitis B virus; HBV-miR-3; cGAS; Sting; IFN-β
Core Tip	This study uncovers a novel mechanism of hepatitis B virus (HBV) immunity evasion through HBV-miR-3, a recently identified HBV-encoded microRNA. HBV-miR-3 down-regulates the cGAS-STING-IFN pathway by inhibiting cGAS 3’ untranslated region activity, leading to decreased cGAS protein expression, STING phosphorylation, and interferon production. The findings highlight the crucial role of HBV-miR-3 in modulating host immune responses, providing insights into potential therapeutic targets for HBV infection.
Publish Date	2025-02-20 08:39
Citation	<p>Xu ZY, Gao JS, He Y, Xiao XQ, Gong GZ, Zhang M. Hepatitis B virus confers innate immunity evasion through hepatitis B virus-miR-3 down-regulation of cGAS-Sting-IFN signaling. <i>World J Hepatol</i> 2025; 17(2): 99292</p>
URL	https://www.wjgnet.com/1948-5182/full/v17/i2/99292.htm
DOI	https://dx.doi.org/10.4254/wjh.v17.i2.99292

Full Article (PDF)	WJH-17-99292-with-cover.pdf
Manuscript File	99292_Auto_Edited_013710.docx
Answering Reviewers	99292-answering-reviewers.pdf
Audio Core Tip	99292-audio.mp3
Biostatistics Review Certificate	99292-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	99292-conflict-of-interest-statement.pdf
Copyright License Agreement	99292-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	99292-foundation-statement.pdf
Institutional Review Board Approval Form or Document	99292-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	99292-non-native-speakers.pdf
Peer-review Report	99292-peer-reviews.pdf
Scientific Misconduct Check	99292-scientific-misconduct-check.png
Scientific Editor Work List	99292-scientific-editor-work-list.pdf
CrossCheck Report	99292-crosscheck-report.png
CrossCheck Report	99292-crosscheck-report.pdf