BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
2/20/2025 8:39:41 AM | Browse: 193 | Download: 821
 |
Received |
|
2024-08-21 05:53 |
|
Peer-Review Started |
|
2024-07-19 01:37 |
|
First Decision by Editorial Office Director |
|
2024-11-23 20:48 |
|
Return for Revision |
|
2024-11-26 01:10 |
|
Revised |
|
2024-12-05 04:52 |
|
Publication Fee Transferred |
|
2024-12-11 03:26 |
|
Second Decision by Editor |
|
2025-01-18 02:46 |
 |
Second Decision by Editor-in-Chief |
|
|
|
Final Decision by Editorial Office Director |
|
2025-01-18 07:41 |
|
Articles in Press |
|
2025-01-18 07:41 |
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
2025-02-11 00:57 |
|
Publish the Manuscript Online |
|
2025-02-20 08:39 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Infectious Diseases |
| Manuscript Type |
Basic Study |
| Article Title |
Hepatitis B virus confers innate immunity evasion through hepatitis B virus-miR-3 down-regulation of cGAS-Sting-IFN signaling
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zhen-Yu Xu, Jia-Shi Gao, Ying He, Xin-Qiang Xiao, Guo-Zhong Gong and Min Zhang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China, Key Project |
82430071 |
| The Scientific Research Program of FuRong Laboratory |
2023SK2108 |
| Clinical Medical Research Center for Viral Hepatitis of Hunan Province |
2023SK4009 |
| Hunan Provincial Natural Science Foundation |
2023JJ60440 |
| Hunan Provincial Health Commission Research Program |
C202303088786 |
|
| Corresponding Author |
Guo-Zhong Gong, MD, Department of Infectious Disease, The Second Xiangya Hospital, Central South University, No. 139 Renmin Middle Road, Changsha 410011, Hunan Province, China. gongguozhong@csu.edu.cn |
| Key Words |
Hepatitis B virus; HBV-miR-3; cGAS; Sting; IFN-β |
| Core Tip |
This study uncovers a novel mechanism of hepatitis B virus (HBV) immunity evasion through HBV-miR-3, a recently identified HBV-encoded microRNA. HBV-miR-3 down-regulates the cGAS-STING-IFN pathway by inhibiting cGAS 3’ untranslated region activity, leading to decreased cGAS protein expression, STING phosphorylation, and interferon production. The findings highlight the crucial role of HBV-miR-3 in modulating host immune responses, providing insights into potential therapeutic targets for HBV infection. |
| Publish Date |
2025-02-20 08:39 |
| Citation |
Xu ZY, Gao JS, He Y, Xiao XQ, Gong GZ, Zhang M. Hepatitis B virus confers innate immunity evasion through hepatitis B virus-miR-3 down-regulation of cGAS-Sting-IFN signaling. World J Hepatol 2025; 17(2): 99292 |
| URL |
https://www.wjgnet.com/1948-5182/full/v17/i2/99292.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v17.i2.99292 |
All content on this site: Copyright © 1993-2026 Baishideng Publishing Group Inc, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.
