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Articles Published Processes
2/24/2025 5:39:18 AM | Browse: 144 | Download: 542
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Received |
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2024-07-19 15:14 |
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Peer-Review Started |
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2024-07-19 15:14 |
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First Decision by Editorial Office Director |
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2024-10-30 09:50 |
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Return for Revision |
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2024-10-30 09:50 |
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Revised |
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2024-11-24 11:17 |
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Publication Fee Transferred |
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2024-11-30 03:13 |
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Second Decision by Editor |
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2025-01-11 01:49 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-01-23 09:06 |
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Articles in Press |
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2025-01-23 09:06 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-02-09 13:21 |
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Publish the Manuscript Online |
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2025-02-24 05:39 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Effects of macrophages on the osteogenic differentiation of adipose tissue-derived stem cells in two-dimensional and three-dimensional cocultures
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
He-Ao Zhang, Bo-Yu Zhang and Hong-Bo Tang |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Hong-Bo Tang, Professor, Department of Plastic and Cosmetic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Jiefang Avenue, Wuhan 430030, Hubei Province, China. tthhbb@sohu.com |
| Key Words |
Fracture; Adipose tissue-derived stem cells; Osteogenic differentiation; Three-dimensional cell culture; N-cadherin |
| Core Tip |
The macrophages in three-dimensional (3D) culture inhibited osteogenic differentiation of adipose tissue-derived stem cells (ADSCs), contrary to the effect in 2D culture. The 3D culture environment might inhibit the Wnt/β-catenin signaling pathway by increasing N-cadherin expression, and consequently, inhibiting osteogenic differentiation of ADSCs. This study offers a refined protocol for the exploration of ADSCs osteogenesis and provides novel ideas for exploring 3D osteogenesis in ADSCs, fracture repair, and other bone trauma repair. |
| Publish Date |
2025-02-24 05:39 |
| Citation |
Zhang HA, Zhang BY, Tang HB. Effects of macrophages on the osteogenic differentiation of adipose tissue-derived stem cells in two-dimensional and three-dimensional cocultures. World J Stem Cells 2025; 17(2): 99326 |
| URL |
https://www.wjgnet.com/1948-0210/full/v17/i2/99326.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v17.i2.99326 |
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