Publication Name	World Journal of Gastroenterology
Manuscript ID	99358
Country	China

Received	2024-08-20 00:40
Peer-Review Started	2024-07-20 15:51
To Make the First Decision
Return for Revision	2024-10-31 03:10
Revised	2024-11-11 13:27
Second Decision	2024-11-22 03:33
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-11-22 12:45
Articles in Press	2024-11-22 12:45
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-12-13 02:24
Publish the Manuscript Online	2024-12-20 03:53

ISSN	1007-9327 (print) and 2219-2840 (online)
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Category	Medicine, Research & Experimental
Manuscript Type	Letter to the Editor
Article Title	Unraveling the therapeutic potential of Calculus Bovis in liver cancer: A novel step for targeted cancer treatment
Manuscript Source	Invited Manuscript
All Author List	Xing-Yu Chen and Xiang Lan
ORCID	Author(s) ORCID Number Xiang Lan http://orcid.org/0009-0004-5016-1301
Funding Agency and Grant Number
Corresponding Author	Xiang Lan, MD, PhD, Professor, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuanjiagang, Yuzhong District, Chongqing 400016, China. lanxiangkeyan@163.com
Key Words	Calculus Bovis; Liver cancer; M2 tumor-associated macrophage polarization; Wnt/β-catenin Pathway; Tumor microenvironment
Core Tip	Calculus Bovis (CB), a valuable herb in traditional Chinese medicine, has shown definite anti-liver cancer effects in vivo. Analyses of the composition of CB and the use of network pharmacology for target prediction revealed that CB has anti-liver cancer effects by affecting immune-related pathways in the tumor microenvironment. Transcriptome sequencing demonstrated that the regulation of the M2-type tumor-associated macrophage (TAM) polarization is responsible for the effects of CB. In vitro studies revealed that modulating the Wnt/β-catenin pathway is a crucial mechanism by which CB regulates M2 polarization of TAMs. The present study provides evidence for the development of liver cancer therapeutics.
Publish Date	2024-12-20 03:53
Citation	<p>Chen XY, Lan X. Unraveling the therapeutic potential of Calculus Bovis in liver cancer: A novel step for targeted cancer treatment. <i>World J Gastroenterol</i> 2025; 31(3): 99358</p>
URL	https://www.wjgnet.com/1007-9327/full/v31/i3/99358.htm
DOI	https://dx.doi.org/10.3748/wjg.v31.i3.99358

Full Article (PDF)	WJG-31-99358-with-cover.pdf
Manuscript File	99358_Auto_Edited_054719.docx
Answering Reviewers	99358-answering-reviewers.pdf
Audio Core Tip	99358-audio.mp3
Conflict-of-Interest Disclosure Form	99358-conflict-of-interest-statement.pdf
Copyright License Agreement	99358-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate	99358-non-native-speakers.pdf
Peer-review Report	99358-peer-reviews.pdf
Scientific Misconduct Check	99358-scientific-misconduct-check.png
Scientific Editor Work List	99358-scientific-editor-work-list.pdf
CrossCheck Report	99358-crosscheck-report.pdf