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Articles Published Processes
12/20/2024 3:53:48 AM | Browse: 140 | Download: 631
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Received |
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2024-08-20 00:40 |
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Peer-Review Started |
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2024-07-20 15:51 |
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First Decision by Editorial Office Director |
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2024-10-31 03:10 |
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Return for Revision |
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2024-10-31 03:10 |
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Revised |
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2024-11-11 13:27 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2024-11-22 03:33 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2024-11-22 12:45 |
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Articles in Press |
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2024-11-22 12:45 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2024-12-13 02:24 |
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Publish the Manuscript Online |
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2024-12-20 03:53 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Letter to the Editor |
| Article Title |
Unraveling the therapeutic potential of Calculus Bovis in liver cancer: A novel step for targeted cancer treatment
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Xing-Yu Chen and Xiang Lan |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Xiang Lan, MD, PhD, Professor, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuanjiagang, Yuzhong District, Chongqing 400016, China. lanxiangkeyan@163.com |
| Key Words |
Calculus Bovis; Liver cancer; M2 tumor-associated macrophage polarization; Wnt/β-catenin Pathway; Tumor microenvironment |
| Core Tip |
Calculus Bovis (CB), a valuable herb in traditional Chinese medicine, has shown definite anti-liver cancer effects in vivo. Analyses of the composition of CB and the use of network pharmacology for target prediction revealed that CB has anti-liver cancer effects by affecting immune-related pathways in the tumor microenvironment. Transcriptome sequencing demonstrated that the regulation of the M2-type tumor-associated macrophage (TAM) polarization is responsible for the effects of CB. In vitro studies revealed that modulating the Wnt/β-catenin pathway is a crucial mechanism by which CB regulates M2 polarization of TAMs. The present study provides evidence for the development of liver cancer therapeutics. |
| Publish Date |
2024-12-20 03:53 |
| Citation |
Chen XY, Lan X. Unraveling the therapeutic potential of Calculus Bovis in liver cancer: A novel step for targeted cancer treatment. World J Gastroenterol 2025; 31(3): 99358 |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i3/99358.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i3.99358 |
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