Publication Name	World Journal of Gastroenterology
Manuscript ID	99397
Country	Algeria

Received	2024-08-20 00:49
Peer-Review Started	2024-07-21 17:07
To Make the First Decision
Return for Revision	2024-11-14 06:30
Revised	2024-11-14 15:00
Second Decision	2024-12-02 02:38
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-12-02 05:35
Articles in Press	2024-12-02 05:35
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-12-04 00:12
Publish the Manuscript Online	2024-12-30 06:47

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Letter to the Editor
Article Title	Unlocking the potential of Calculus bovis: A breakthrough in liver cancer treatment via Wnt/β-catenin pathway modulation
Manuscript Source	Invited Manuscript
All Author List	Farouk Benmediouni
ORCID	Author(s) ORCID Number Farouk Benmediouni http://orcid.org/0009-0006-0526-4939
Funding Agency and Grant Number
Corresponding Author	Farouk Benmediouni, Assistant Professor, Chief Physician, MD, Department of Internal Medicine, Mixed Hospital of Laghouat, Laghouat Faculty of Medicine, Amar Telidji University, Elwiam District, Laghouat 03000, Algeria. fbenmediouni@yahoo.fr
Key Words	Calculus bovis; Liver cancer; M2 phenotype tumor-associated macrophages; Wnt/β-catenin pathway; Traditional Chinese medicine; Tumor microenvironment; Antineoplastic therapy
Core Tip	This article discusses the significant findings of Huang et al, who demonstrated that Calculus bovis, a traditional Chinese medicine, exhibits potent anti-liver cancer effects. The study revealed that Calculus bovis effectively inhibits M2 tumor-associated macrophage polarization by modulating the Wnt/β-catenin pathway, leading to reduced tumor growth and improved tumor regression in vivo. These insights underscore the potential of integrating traditional Chinese medicinal approaches with modern therapeutic strategies to develop novel, multi-targeted treatments for liver cancer, addressing a critical need in oncology.
Publish Date	2024-12-30 06:47
Citation	<p>Benmediouni F. Unlocking the potential of Calculus bovis: A breakthrough in liver cancer treatment via Wnt/β-catenin pathway modulation. <i>World J Gastroenterol</i> 2025; 31(4): 99397</p>
URL	https://www.wjgnet.com/1007-9327/full/v31/i4/99397.htm
DOI	https://dx.doi.org/10.3748/wjg.v31.i4.99397

Full Article (PDF)	WJG-31-99397-with-cover.pdf
Manuscript File	99397_Auto_Edited_013825.docx
Answering Reviewers	99397-answering-reviewers.pdf
Audio Core Tip	99397-audio.m4a
Conflict-of-Interest Disclosure Form	99397-conflict-of-interest-statement.pdf
Copyright License Agreement	99397-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate	99397-non-native-speakers.pdf
Peer-review Report	99397-peer-reviews.pdf
Scientific Misconduct Check	99397-scientific-misconduct-check.png
Scientific Editor Work List	99397-scientific-editor-work-list.pdf
CrossCheck Report	99397-crosscheck-report.pdf