| ISSN |
2220-3206 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Psychology, Clinical |
| Manuscript Type |
Clinical Trials Study |
| Article Title |
Using the THINC-integrated tool to compare the characteristics of cognitive dysfunction in patients with unipolar and bipolar depression
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Na Zhu, Qi Zhang, Jia Huang, Jie Tong, Heng-Fen Gong, Ming-Huan Zhu, Wei Lu, Jie Zhang and Xi-Rong Sun |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Science and Technology Development Fund of Shanghai Pudong New Area |
PKJ2023-Y20 |
| Key Discipline Construction Fund of the Shanghai Pudong New Area Municipal Commission of Health and Family Planning |
PWZxk2022-18 |
| Pudong New Area Construction Project of National Traditional Chinese Medicine Development Comprehensive Reform Pilot Zone |
PDZY-2022-0501 |
|
| Corresponding Author |
Xi-Rong Sun, MD, Clinical Research Center for Mental Disorders, Shanghai Pudong New Area Mental Health Center, School of Medicine, Tongji University, No. 165 Sanlin Road, Pudong New Area, Shanghai 200124, China. sunxr1807@163.com |
| Key Words |
Unipolar and bipolar depression; THINC-integrated tool; Objective cognitive impairments; Subjective cognitive impairment; Depression; Influencing factor |
| Core Tip |
The THINC-integrated tool was applied to 75 patients with depressive disorders, 120 individuals with bipolar depression, and 100 healthy controls. In our study, neurocognitive function characteristics were analyzed as well as the relationships between cognitive impairment and general clinical attributes. We found that objective cognitive impairment exhibited similarities between individuals with unipolar and bipolar depression, whereas subjective cognitive impairment showed differences. Additionally, there were no disparities in the impacts of age, age at onset, years of education, and depression level on cognitive impairment in individuals with unipolar and bipolar depression. Furthermore, years of education emerged as a protective factor against objective cognitive impairment. Interestingly, other clinical features had different effects on cognitive impairment varying between the two depression groups. These provide some theoretical support for the identification of unipolar and bipolar depression. |
| Publish Date |
2025-02-26 04:38 |
| Citation |
<p>Zhu N, Zhang Q, Huang J, Tong J, Gong HF, Zhu MH, Lu W, Zhang J, Sun XR. Using the THINC-integrated tool to compare the characteristics of cognitive dysfunction in patients with unipolar and bipolar depression. <i>World J Psychiatry</i> 2025; 15(3): 99408</p> |
| URL |
https://www.wjgnet.com/2220-3206/full/v15/i3/99408.htm |
| DOI |
https://dx.doi.org/10.5498/wjp.v15.i3.99408 |
