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10/29/2014 7:34:00 PM | Browse: 637 | Download: 744
Publication Name World Journal of Gastroenterology
Manuscript ID 9944
Country of Manuscript Source Australia
2014-03-05 20:11
Peer-Review Started
2014-03-06 08:50
To Make the First Decision
2014-04-28 14:20
Return for Revision
2014-05-03 19:24
2014-05-19 15:18
Second Decision
2014-06-26 17:09
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-06-26 17:18
Articles in Press
2014-06-26 17:51
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2014-10-15 14:38
Publish the Manuscript Online
2014-10-29 19:34
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Oncology
Manuscript Type Autobiography
Article Title MicroRNA signatures in chemotherapy resistant esophageal cancer cell lines
Manuscript Source Invited Manuscript
All Author List Richard Hummel, Corina Sie, David I Watson, Tingting Wang, Alfiya Ansar, Michael Z Michael, Mark Van der Hoek, Joerg Haier and Damian J Hussey
Funding Agency and Grant Number
Funding Agency Grant Number
A Research Fellowship of the German Research Foundation (DFG) Hu 1763/1-1 (to Hummel R)
Funding was also obtained from a project grant from the National Health and Medical Research Council of Australia 595964
Funding Sources (DFG, National Health and Medical Research Council of Australia)
Corresponding author Damian J Hussey, PhD, Department of Surgery, Flinders University, Room 3D213, Flinders Medical Centre, Bedford Park, South Australia 5042, Australia. damian.hussey@flinders.edu.au
Keywords Esophageal cancer; MicroRNA; Chemotherapy; Resistance; Target
Core Tip The current study demonstrates that chemotherapy resistant esophageal adeno- and squamous cell carcinoma cells present distinct microRNA (miRNA) signatures, with a number of well known resistance relevant miRNAs differentially expressed in the derived cisplatin or 5-fluorouracil resistant cell lines. Furthermore, a number of putative target genes that are known to have an impact on chemotherapy resistance are dysregulated in the chemotherapy resistant cell lines in a direction consistent with negative posttranscriptional control of target gene expression via the respective miRNA, thereby implicating a potential mediatory effect in terms of chemotherapy resistance development.
Publish Date 2014-10-29 19:34
Citation Hummel R, Sie C, Watson DI, Wang T, Ansar A, Michael MZ, Van der Hoek M, Haier J, Hussey DJ. MicroRNA signatures in chemotherapy resistant esophageal cancer cell lines. World J Gastroenterol 2014; 20(40): 14904-14912
Url http://www.wjgnet.com/1007-9327/full/v20/i40/14904.htm
DOI http://dx.doi.org/10.3748/wjg.v20.i40.14904
Full Article (PDF) WJG-20-14904.pdf
Full Article (Word) WJG-20-14904.doc
Manuscript File 9944-Review.doc
Answering Reviewers 9944-Answering reviewers.pdf
Copyright License Agreement 9944-Copyright assignment.pdf
Peer-review Report 9944-Peer review.pdf
Scientific Misconduct Check 9944-CorssCheck.jpg
Scientific Editor Work List 9944-Scientific editor work list.pdf