Publication Name	World Journal of Gastroenterology
Manuscript ID	9944
Country	Australia

Received	2014-03-05 20:11
Peer-Review Started	2014-03-06 08:50
First Decision by Editorial Office Director
Return for Revision	2014-05-03 19:24
Revised	2014-05-19 15:18
Publication Fee Transferred
Second Decision by Editor	2014-06-26 17:09
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2014-06-26 17:18
Articles in Press	2014-06-26 17:51
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-10-15 14:38
Publish the Manuscript Online	2014-10-29 19:34

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Autobiography
Article Title	MicroRNA signatures in chemotherapy resistant esophageal cancer cell lines
Manuscript Source	Invited Manuscript
All Author List	Richard Hummel, Corina Sie, David I Watson, Tingting Wang, Alfiya Ansar, Michael Z Michael, Mark Van der Hoek, Joerg Haier and Damian J Hussey
Funding Agency and Grant Number	Funding Agency Grant Number A Research Fellowship of the German Research Foundation (DFG) Hu 1763/1-1 (to Hummel R) Funding was also obtained from a project grant from the National Health and Medical Research Council of Australia 595964 Funding Sources (DFG, National Health and Medical Research Council of Australia)
Corresponding Author	Damian J Hussey, PhD, Department of Surgery, Flinders University, Room 3D213, Flinders Medical Centre, Bedford Park, South Australia 5042, Australia. damian.hussey@flinders.edu.au
Key Words	Esophageal cancer; MicroRNA; Chemotherapy; Resistance; Target
Core Tip	The current study demonstrates that chemotherapy resistant esophageal adeno- and squamous cell carcinoma cells present distinct microRNA (miRNA) signatures, with a number of well known resistance relevant miRNAs differentially expressed in the derived cisplatin or 5-fluorouracil resistant cell lines. Furthermore, a number of putative target genes that are known to have an impact on chemotherapy resistance are dysregulated in the chemotherapy resistant cell lines in a direction consistent with negative posttranscriptional control of target gene expression via the respective miRNA, thereby implicating a potential mediatory effect in terms of chemotherapy resistance development.
Publish Date	2014-10-29 19:34
Citation	Hummel R, Sie C, Watson DI, Wang T, Ansar A, Michael MZ, Van der Hoek M, Haier J, Hussey DJ. MicroRNA signatures in chemotherapy resistant esophageal cancer cell lines. World J Gastroenterol 2014; 20(40): 14904-14912
URL	http://www.wjgnet.com/1007-9327/full/v20/i40/14904.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i40.14904

Full Article (PDF)	WJG-20-14904.pdf
Full Article (Word)	WJG-20-14904.doc
Manuscript File	9944-Review.doc
Answering Reviewers	9944-Answering reviewers.pdf
Copyright License Agreement	9944-Copyright assignment.pdf
Peer-review Report	9944-Peer review.pdf
Scientific Misconduct Check	9944-CorssCheck.jpg
Scientific Editor Work List	9944-Scientific editor work list.pdf