| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Surgery |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Expression rates of p16, p53 in head and neck cutaneous squamous cell carcinoma based on human-papillomavirus positivity
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ha-Jong Nam, Heongrae Ryu, Da-Woon Lee, Je Yeon Byeon, Jun Hyuk Kim, Ji Hye Lee, Soomin Lim and Hwan Jun Choi |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Research Foundation of Korea |
No. 2020R1A2C1100891 |
| Soonchunhyang University Research Fund |
No. 2024-05-014 |
|
| Corresponding Author |
Hwan Jun Choi, PhD, Professor, Department of Plastic and Reconstructive Surgery, College of Medicine, Soonchunhyang University, No. 44 Suncheonhyang 4-gil, Dongnam-gu, Cheonan-si 31151, South Korea. iprskorea@gmail.com |
| Key Words |
Squamous cell carcinoma; Oropharyngeal; Non-oropharyngeal; Human papillomavirus; The p16; The p53 |
| Core Tip |
Human papillomavirus (HPV) plays an important role in certain head and neck cancers; however, its role in these cancers remains unclear. We examined 62 patients to determine the prevalence of HPV and its relationship with p16 and p53 expression levels. These results indicate that p16 is not a reliable HPV marker in these skin cancers, unlike in other head and neck cancers. This study provides insights into the interactions between HPV, p16, and p53 in head and neck skin cancers, particularly in Asian populations, potentially improving our understanding and treatment of these cancers. |
| Publish Date |
2024-12-12 07:29 |
| Citation |
<p>Nam HJ, Ryu H, Lee DW, Byeon JY, Kim JH, Lee JH, Lim S, Choi HJ. Expression rates of p16, p53 in head and neck cutaneous squamous cell carcinoma based on human-papillomavirus positivity. <i>World J Clin Cases</i> 2025; 13(9): 99463</p> |
| URL |
https://www.wjgnet.com/2307-8960/full/v13/i9/99463.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v13.i9.99463 |
