| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
DNMT1/miR-342-3p/FoxM1 signal axis beneficial for cancer stem-like cell self-renewal in cervical cancer
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xiao-Zheng Cao, Yao-Feng Zhang, Yu-Wei Song, Lei Yuan, Hui-Li Tang, Jin-Yuan Li, Ye-Bei Qiu, Jia-Zhi Lin, Ying-Xia Ning, Xiao-Yu Wang, Yong Xu and Shao-Qiang Lin |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Guangzhou Basic and Applied Basic Research Foundation |
202201010121 |
| Medical Joint Fund of Jinan University |
YXZY2024014, YXJC2022001 |
| Hospital Achievement Transformation and Cultivation Project |
ZH201911 |
| Key Discipline Project of Guangdong Province |
2019-GDXK-0016 |
| Medical Science and Technology Research Foundation of Guangdong Province |
B2021145 |
|
| Corresponding Author |
Shao-Qiang Lin, MD, PhD, Guangdong Provincial Engineering Research Center for Esophageal Cancer Precise Therapy, The First Affiliated Hospital of Guangdong Pharmaceutical University, No. 19 Nonglinxia Road, Guangzhou 510062, Guangdong Province, China. sqlin123@163.com |
| Key Words |
Forkhead box M1; MiR-342-3p; Cervical cancer; Cancer stem cell; DNA methyltransferase 1 |
| Core Tip |
The study reveals a novel DNMT1/miR-342-3p/FoxM1 signaling axis that enhances self-renewal of cervical cancer stem cell-like cells (CCSLCs). Knockdown of DNMT1 or miR-342-3p elevation inhibits CCSLC self-renewal, while FoxM1 suppression also attenuates this process. Overexpression of DNMT1 or FoxM1 reverses the effects of miR-342-3p mimic. This signaling pathway presents a potential therapeutic target for inhibiting CCSLC self-renewal in cervical cancer, offering new insights for targeted treatment strategies. |
| Publish Date |
2025-03-21 06:10 |
| Citation |
<p>Cao XZ, Zhang YF, Song YW, Yuan L, Tang HL, Li JY, Qiu YB, Lin JZ, Ning YX, Wang XY, Xu Y, Lin SQ. DNMT1/miR-342-3p/FoxM1 signal axis beneficial for cancer stem-like cell self-renewal in cervical cancer. <i>World J Stem Cells</i> 2025; 17(3): 99472</p> |
| URL |
https://www.wjgnet.com/1948-0210/full/v17/i3/99472.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v17.i3.99472 |
