Publication Name	World Journal of Clinical Oncology
Manuscript ID	99484
Country	China

Received	2024-07-23 15:16
Peer-Review Started	2024-07-23 15:16
To Make the First Decision
Return for Revision	2024-09-08 15:05
Revised	2024-09-19 14:32
Second Decision	2024-10-14 00:57
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-10-15 05:31
Articles in Press	2024-10-15 05:31
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-10-16 02:29
Publish the Manuscript Online	2024-10-22 08:28

ISSN	2218-4333 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Letter to the Editor
Article Title	Exploring a new chapter in traditional Chinese medicine: The potential of Calculus bovis in liver cancer treatment
Manuscript Source	Invited Manuscript
All Author List	Huang Du, Hong-Bin Chen and Yu Zhao
ORCID	Author(s) ORCID Number Huang Du http://orcid.org/0000-0002-3735-9231 Hong-Bin Chen http://orcid.org/0000-0002-8956-6814
Funding Agency and Grant Number
Corresponding Author	Hong-Bin Chen, Chief Physician, Department of Gastroenterology I, Sanming First Hospital, Fujian Medical University, No. 29 Liedong Street, Sanyuan District, Sanming 365000, Fujian Province, China. smchb2008@qq.com
Key Words	Calculus bovis; M2 tumor-associated macrophage polarization; Liver cancer; Wnt/β-catenin pathway; The tumor microenvironment
Core Tip	Calculus bovis (C. bovis) has shown remarkable potential in liver cancer treatment research. It was found to modulate the Wnt/β-catenin signalling pathway and inhibit the polarisation of tumour-associated macrophages, thereby inhibiting liver cancer progression. These findings not only reveal the immunoregulatory mechanism of C. bovis but also provide a new strategy and theoretical basis for the treatment of liver cancer. However, since the specific anticancer components of C. bovis are not known, future studies should focus on the inhibition of the liver cancer pathway mediated by specific components of C. bovis to facilitate clinical advancements in liver cancer treatment.
Publish Date	2024-10-22 08:28
Citation	<p>Du H, Chen HB, Zhao Y. Exploring a new chapter in traditional Chinese medicine: The potential of Calculus bovis in liver cancer treatment. <i>World J Clin Oncol</i> 2024; 15(12): 1520-1527</p>
URL	https://www.wjgnet.com/2218-4333/full/v15/i12/1520.htm
DOI	https://dx.doi.org/10.5306/wjco.v15.i12.1520

Full Article (PDF)	WJCO-15-1520-with-cover.pdf
Manuscript File	99484_Auto_Edited_054311.docx
Answering Reviewers	99484-answering-reviewers.pdf
Audio Core Tip	99484-audio.m4a
Conflict-of-Interest Disclosure Form	99484-conflict-of-interest-statement.pdf
Copyright License Agreement	99484-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate	99484-non-native-speakers.pdf
Peer-review Report	99484-peer-reviews.pdf
Scientific Misconduct Check	99484-scientific-misconduct-check.png
Scientific Editor Work List	99484-scientific-editor-work-list.pdf
CrossCheck Report	99484-crosscheck-report.png
CrossCheck Report	99484-crosscheck-report.pdf