Publication Name	World Journal of Immunology
Manuscript ID	9950
Country	Japan

Received	2014-03-05 20:27
Peer-Review Started	2014-03-06 08:59
To Make the First Decision	2014-03-26 15:24
Return for Revision	2014-05-12 14:18
Revised	2014-05-17 12:13
Second Decision	2014-07-17 14:18
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-07-17 14:36
Articles in Press	2014-07-17 14:51
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-11-11 16:16
Publish the Manuscript Online	2014-11-19 15:06

ISSN	2219-2824 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Immunology
Manuscript Type	Review
Article Title	Immunological aspects of drug-induced liver injury
Manuscript Source	Invited Manuscript
All Author List	Kazuto Tajiri and Yukihiro Shimizu
Funding Agency and Grant Number
Corresponding Author	Yukihiro Shimizu, MD, PhD, Gastroenterology Unit, Nanto Municipal Hospital, Nanto, Toyama 932-0211, Japan. rsf14240@nifty.com
Key Words	Immune cells; Cytokine; Human leukocyte antigen; Innate immunity; Drug-induced liver injury
Core Tip	Drug-induced liver injury (DILI) is a common liver disease that occurs frequently after drug ingestion. DILI can be classified as predictable or idiosyncratic. The former is dose dependent, has a short latency period, and results from direct toxicity of the drug or its metabolite(s). Idiosyncratic DILI may be more problematic because it is usually unpredictable and is found more frequently in the clinical setting. This type of DILI is due to an allergic reaction or the toxicity of metabolites generated via individual drug metabolism reactions. Various factors, such as environmental, genetic and immunological reactions, may be associated with adduct formation and the onset of DILI. This review summarizes current knowledge on the immunological aspects of DILI, including its pathogenesis, diagnosis and treatment.
Publish Date	2014-11-19 15:06
Citation	Tajiri K, Shimizu Y. Immunological aspects of drug-induced liver injury. World J Immunol 2014; 4(3): 149-157
URL	http://www.wjgnet.com/2219-2824/full/v4/i3/149.htm
DOI	http://dx.doi.org/10.5411/wji.v4.i3.149

Full Article (PDF)	WJI-4-149.pdf
Full Article (Word)	WJI-4-149.doc
Manuscript File	9950-Review.doc
Answering Reviewers	9950-Answering reviewers.pdf
Copyright License Agreement	9950-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	9950-Language certificate.pdf
Peer-review Report	9950-Peer review(s).pdf
Scientific Misconduct Check	9950-CrossCheck.jpg
Scientific Editor Work List	9950-Scientific editor work list.pdf