Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	99533
Country	China

Received	2024-07-24 12:56
Peer-Review Started	2024-07-24 12:56
To Make the First Decision
Return for Revision	2024-09-10 01:17
Revised	2024-09-17 16:09
Second Decision	2024-09-25 02:36
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-09-25 07:58
Articles in Press	2024-09-25 07:58
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-10-11 05:41
Publish the Manuscript Online	2024-10-25 10:27

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Letter to the Editor
Article Title	Vascular endothelial growth factor pathway’s influence on bevacizumab efficacy in metastatic colorectal cancer treatment
Manuscript Source	Invited Manuscript
All Author List	Yuan Qin, Fu-Yuan Ma, Zhi Zhang, Chen-Hao Zhao and Biao Huang
ORCID	Author(s) ORCID Number Yuan Qin http://orcid.org/0000-0002-5651-8293 Biao Huang http://orcid.org/0000-0003-1883-0670
Funding Agency and Grant Number	Funding Agency Grant Number Natural Science Foundation of Zhejiang Province LQ23H050005 Scientific research project of Zhejiang Provincial Education Department Y202250731 Scientific research project of Zhejiang Provincial Education Department Y202353130 China Students’ Innovation and Entrepreneurship Training Program 202310338044 China Postdoctoral Science Foundation 2022M721720
Corresponding Author	Biao Huang, PhD, Research Fellow, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, No. 928, No. 2 Street, Qiantang District, Hangzhou 310018, Zhejiang Province, China. jswxhb@163.com
Key Words	Bevacizumab; Chemotherapy; Metastatic colorectal cancer; PD-1/PD-L1 axis; Therapeutic approach; Vascular endothelial growth factor
Core Tip	In the management of colorectal carcinoma, bevacizumab wields its therapeutic impact via the neutralization of vascular endothelial growth factor (VEGF), a paramount mediator of intratumoral angiogenesis. This inhibitory action on VEGF obstructs neovascularization, consequently sequestering the essential sustenance of nutrients and oxygen requisite for tumoral proliferation and viability. Contrarily, the interaction between programmed death-ligand 1 and VEGF receptor 2 catalyzes the genesis of novel vasculature that sustains and nurtures the neoplasm, thereby potentiating angiogenic processes.
Publish Date	2024-10-25 10:27
Citation	<p>Qin Y, Ma FY, Zhang Z, Zhao CH, Huang B. Vascular endothelial growth factor pathway’s influence on bevacizumab efficacy in metastatic colorectal cancer treatment. <i>World J Gastrointest Oncol</i> 2024; 16(11): 4514-4517</p>
URL	https://www.wjgnet.com/1948-5204/full/v16/i11/4514.htm
DOI	https://dx.doi.org/10.4251/wjgo.v16.i11.4514

Full Article (PDF)	WJGO-16-4514-with-cover.pdf
Manuscript File	99533_Auto_Edited_092347.docx
Answering Reviewers	99533-answering-reviewers.pdf
Audio Core Tip	99533-audio.m4a
Conflict-of-Interest Disclosure Form	99533-conflict-of-interest-statement.pdf
Copyright License Agreement	99533-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	99533-foundation-statement.pdf
Non-Native Speakers of English Editing Certificate	99533-non-native-speakers.pdf
Peer-review Report	99533-peer-reviews.pdf
Scientific Misconduct Check	99533-scientific-misconduct-check.png
Scientific Editor Work List	99533-scientific-editor-work-list.pdf
CrossCheck Report	99533-crosscheck-report.pdf