Publication Name	World Journal of Clinical Cases
Manuscript ID	99558
Country	Ecuador

Received	2024-07-25 02:52
Peer-Review Started	2024-07-25 02:52
To Make the First Decision
Return for Revision	2024-09-25 06:32
Revised	2024-10-09 01:52
Second Decision	2024-10-29 02:48
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-10-29 10:26
Articles in Press	2024-10-29 10:26
Publication Fee Transferred	2024-10-21 19:03
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-11-05 02:38
Publish the Manuscript Online	2024-11-12 06:40

ISSN	2307-8960 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Case Report
Article Title	Wilson's disease in two siblings from Ecuador: Two case reports
Manuscript Source	Unsolicited Manuscript
All Author List	Enrique Carrera, Jonathan Alvarado, Martina Astudillo and Galo Pillajo
ORCID	Author(s) ORCID Number Enrique Carrera http://orcid.org/0000-0002-8320-8629 Jonathan Alvarado http://orcid.org/0000-0002-1302-041X Martina Astudillo http://orcid.org/0009-0003-1896-4836 Galo Pillajo http://orcid.org/0000-0003-4450-3163
Funding Agency and Grant Number
Corresponding Author	Enrique Carrera, MD, Assistant Professor, Department of Gastroenterology and Hepatology, Hospital de Especialidades Eugenio Espejo, Gran Colombia Avenue and Yaguachi Street, Quito 170136, Pichincha, Ecuador. carreraestupinan.enrique@gmail.com
Key Words	Wilson disease; Kayser-Fleischer rings; Copper chelator; D-penicillamine; Trientine tetrahydrochloride; Case report
Core Tip	Diagnosing and treating Wilson disease (WD) is particularly challenging in developing countries due to limited resources. This case study of two siblings from Ecuador demonstrates why early diagnoses and consistent treatments are crucial. The male sibling showed severe symptoms, whereas an early intervention kept the female sibling asymptomatic. Switching from D-penicillamine to trientine tetrahydrochloride improved their condition. Our cases report emphasizes the need for an effective healthcare infrastructure and WD awareness to manage the condition under resource-limited settings, and our findings suggest that genetic and environmental factors contribute to the disease's variability.
Publish Date	2024-11-12 06:40
Citation	<p>Carrera E, Alvarado J, Astudillo M, Pillajo G. Wilson's disease in two siblings from Ecuador: Two case reports. <i>World J Clin Cases</i> 2025; 13(3): 99558</p>
URL	https://www.wjgnet.com/2307-8960/full/v13/i3/99558.htm
DOI	https://dx.doi.org/10.12998/wjcc.v13.i3.99558

Full Article (PDF)	WJCC-13-99558-with-cover.pdf
CARE Checklist–2016	99558-CARE-Checklist-2016.pdf
Manuscript File	99558_Auto_Edited_015712.docx
Answering Reviewers	99558-answering-reviewers.pdf
Audio Core Tip	99558-audio.mp3
Conflict-of-Interest Disclosure Form	99558-conflict-of-interest-statement.pdf
Copyright License Agreement	99558-copyright-assignment.pdf
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Non-Native Speakers of English Editing Certificate	99558-non-native-speakers.pdf
Peer-review Report	99558-peer-reviews.pdf
Scientific Misconduct Check	99558-scientific-misconduct-check.png
Scientific Editor Work List	99558-scientific-editor-work-list.pdf
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