Publication Name	World Journal of Diabetes
Manuscript ID	99576
Country	China

Received	2024-11-13 08:13
Peer-Review Started	2024-11-20 01:46
To Make the First Decision
Return for Revision	2025-01-15 10:01
Revised	2025-02-17 03:46
Second Decision	2025-03-12 09:02
Accepted by Journal Editor-in-Chief	2025-03-12 20:37
Accepted by Executive Editor-in-Chief	2025-03-21 08:40
Articles in Press	2025-03-21 08:40
Publication Fee Transferred	2025-02-23 07:40
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-04-14 02:44
Publish the Manuscript Online	2025-04-25 07:54

ISSN	1948-9358 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Otorhinolaryngology
Manuscript Type	Retrospective Study
Article Title	Therapeutic effectiveness of intratympanic and retroauricular methylprednisolone sodium succinate for refractory sudden sensorineural hearing loss in diabetic patients
Manuscript Source	Unsolicited Manuscript
All Author List	Dong Li, Fei Qiao, Jun Dai, Min Xu, He-Yan Gong, Hui-Ming Yang, Jing-Cheng Li and De Huai
ORCID	Author(s) ORCID Number Jing-Cheng Li http://orcid.org/0009-0008-7528-8586 De Huai http://orcid.org/0000-0002-8259-1582
Funding Agency and Grant Number	Funding Agency Grant Number 2023 Science and Technology Innovation Program (Key Laboratory of Sleep Respiratory Disorders) in Huai'an HAP202304
Corresponding Author	Jing-Cheng Li, Department of Otorhinolaryngology, The Affiliated Huai'an Hospital of Yangzhou University (The Fifth People's Hospital of Huai'an), No. 1 Huaihe Road, Huaiyin District, Huai’an 223300, Jiangsu Province, China. jingchengl@126.com
Key Words	Intratympanic injection; Retroauricular injection; Refractory sudden hearing loss; Diabetes mellitus; Therapeutic effectiveness
Core Tip	Studies on the efficacy of combined intratympanic and retroauricular injection for refractory sudden sensorineural hearing loss (RSSHL) complicated with diabetes mellitus (DM) remains limited. Herein, we comprehensively assessed treatment outcomes, adverse effects, blood glucose levels, hearing thresholds across various frequencies, serum biochemical markers, and quality of life. The results indicate that intratympanic injection combined with retroauricular administration of methylprednisolone sodium succinate significantly improves therapeutic efficacy in patients with RSSHL complicated with DM. This approach not only improves blood glucose control and suppresses systemic inflammation but also enhances quality of life without increasing the overall risk of adverse effects. These results provide valuable information and a potential framework for optimizing treatment strategies in this patient population.
Publish Date	2025-04-25 07:54
Citation	<p>Li D, Qiao F, Dai J, Xu M, Gong HY, Yang HM, Li JC, Huai D. Therapeutic effectiveness of intratympanic and retroauricular methylprednisolone sodium succinate for refractory sudden sensorineural hearing loss in diabetic patients. <i>World J Diabetes</i> 2025; 16(5): 99576</p>
URL	https://www.wjgnet.com/1948-9358/full/v16/i5/99576.htm
DOI	https://dx.doi.org/10.4239/wjd.v16.i5.99576

Full Article (PDF)	WJD-16-99576-with-cover.pdf
Manuscript File	99576_Auto_Edited_081201.docx
Answering Reviewers	99576-answering-reviewers.pdf
Audio Core Tip	99576-audio.mp3
Biostatistics Review Certificate	99576-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	99576-conflict-of-interest-statement.pdf
Copyright License Agreement	99576-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	99576-foundation-statement.pdf
Signed Informed Consent Form(s) or Document(s)	99576-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document	99576-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	99576-non-native-speakers.pdf
Peer-review Report	99576-peer-reviews.pdf
Journal Editor-in-Chief Review Report	99576-journal-editor-in-chief.pdf
Scientific Misconduct Check	99576-scientific-misconduct-check.png
Scientific Editor Work List	99576-scientific-editor-work-list.pdf
CrossCheck Report	99576-crosscheck-report.pdf