| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Letter to the Editor |
| Article Title |
Hepatitis B virus-induced cirrhosis: Mechanisms, global variations, and treatment advances
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Jun-Ya Cheng, Guan-Yue Shan, Hui Wan, Yi-Ying Liu, Yu-Xin Zhang, Wen-Na Shi and Hai-Jun Li |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81970529 |
| Natural Science Foundation of Jilin Province |
20230508074RC and YDZJ202401218ZYTS |
|
| Corresponding Author |
Hai-Jun Li, MD, PhD, Associate Professor, Institute of Liver Diseases, Institute of Translational Medicine, The First Hospital of Jilin University, No. 71 Xinmin Street, Changchun 130061, Jilin Province, China. hjli2012@jlu.edu.cn |
| Key Words |
Chronic hepatitis B virus; Hepatitis B virus-induced cirrhosis; Nucleos(t)ide analogues |
| Core Tip |
Understanding the global variation in hepatitis B virus-induced cirrhosis highlights the complex interplay between viral factors, host genetics, and environmental influences. Cirrhosis due to chronic hepatitis B virus (CHB) infection results from a cascade of fibrosis processes driven by persistent viral replication and immune-mediated hepatocyte injury. Over time, evolving antiviral treatment strategies have transformed from interferon-based therapies to nucleos(t)ide analogs, such as tenofovir, which effectively inhibit viral replication and attenuate liver injury. Future research should focus on elucidating new therapeutic targets to improve treatment efficacy and reduce the global burden of cirrhosis associated with CHB infection. |
| Publish Date |
2024-11-29 14:50 |
| Citation |
<p>Cheng JY, Shan GY, Wan H, Liu YY, Zhang YX, Shi WN, Li HJ. Hepatitis B virus-induced cirrhosis: Mechanisms, global variations, and treatment advances. <i>World J Hepatol</i> 2024; 16(12): 1515-1523</p> |
| URL |
https://www.wjgnet.com/1948-5182/full/v16/i12/1515.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v16.i12.1515 |
