Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	99719
Country	India

Received	2024-07-28 17:55
Peer-Review Started	2024-07-28 17:55
To Make the First Decision
Return for Revision	2024-08-17 20:14
Revised	2024-08-29 05:34
Second Decision	2024-09-06 03:03
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-09-06 06:26
Articles in Press	2024-09-06 06:26
Publication Fee Transferred
Edit the Manuscript by Language Editor	2024-09-09 14:51
Typeset the Manuscript	2024-09-13 09:36
Publish the Manuscript Online	2024-11-27 09:42

ISSN	1948-9366 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Anesthesiology
Manuscript Type	Editorial
Article Title	Dexmedetomidine in colon cancer surgery: Evaluating its impact and efficacy
Manuscript Source	Invited Manuscript
All Author List	Sohan Lal Solanki and Jyoti Sharma
ORCID	Author(s) ORCID Number Sohan Lal Solanki http://orcid.org/0000-0003-4313-7659 Jyoti Sharma http://orcid.org/0000-0002-2898-9645
Funding Agency and Grant Number
Corresponding Author	Sohan Lal Solanki, MD, Professor, Department of Anaesthesiology, Critical Care and Pain, Tata Memorial Hospital, Homi Bhabha National Institute, E Borges Marg, Mumbai 400012, MH, India. me_sohans@yahoo.co.in
Key Words	Colon cancer; Dexmedetomidine; Impact; Human studies; Animal models; In vitro studies
Core Tip	Dexmedetomidine reduces the need for other anesthetic drugs and improves cerebral oxygenation during colon cancer surgery in elderly patients, potentially minimizing intraoperative brain injury, as indicated by lower postoperative serum levels of S100β and neuron-specific enolase. It shows promise in mitigating postoperative cognitive dysfunction and enhancing overall recovery outcomes by reducing neuroinflammation and stabilizing hemodynamics. However, the study's small sample size, single-center design, and short follow-up period limit the generalizability of these findings, highlighting the need for further research with larger, multicenter trials.
Publish Date	2024-11-27 09:42
Citation	<p>Solanki SL, Sharma J. Dexmedetomidine in colon cancer surgery: Evaluating its impact and efficacy. <i>World J Gastrointest Surg</i> 2024; 16(12): 3663-3665</p>
URL	https://www.wjgnet.com/1948-9366/full/v16/i12/3663.htm
DOI	https://dx.doi.org/10.4240/wjgs.v16.i12.3663

Full Article (PDF)	WJGS-16-3663-with-cover.pdf
Manuscript File	99719_Auto_Edited_031046.docx
Answering Reviewers	99719-answering-reviewers.pdf
Audio Core Tip	99719-audio.mp4
Conflict-of-Interest Disclosure Form	99719-conflict-of-interest-statement.pdf
Copyright License Agreement	99719-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate	99719-non-native-speakers.pdf
Peer-review Report	99719-peer-reviews.pdf
Scientific Misconduct Check	99719-scientific-misconduct-check.png
Scientific Editor Work List	99719-scientific-editor-work-list.pdf
CrossCheck Report	99719-crosscheck-report.pdf