Publication Name	World Journal of Gastroenterology
Manuscript ID	99727
Country	China

Received	2024-07-29 01:59
Peer-Review Started	2024-07-29 01:59
To Make the First Decision
Return for Revision	2024-09-04 02:14
Revised	2024-09-15 10:16
Second Decision	2024-10-29 02:41
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-10-29 05:41
Articles in Press	2024-10-29 05:41
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-11-05 01:40
Publish the Manuscript Online	2024-11-13 10:10

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Microbiology
Manuscript Type	Letter to the Editor
Article Title	Gut microbiota participates and remodels host metabolism: From treating patients to treating their gut flora
Manuscript Source	Invited Manuscript
All Author List	Shuang Han, Rui-Hua Li and Peng Gao
ORCID	Author(s) ORCID Number Peng Gao http://orcid.org/0000-0001-6932-5370
Funding Agency and Grant Number
Corresponding Author	Peng Gao, PhD, Professor, Department of Clinical Laboratory, The Second Affiliated Hospital of Dalian Medical University, No. 467 Zhongshan Road, Dalian 116023, Liaoning Province, China. gaop@dmu.edu.cn
Key Words	Gut microbiota; Metabolism; Metabolomics; Hyperuricemia; Peptides
Core Tip	In this article, we comment on Liu et al’s article about intragastric administration of leech total protein could modulate gut microbiota and alleviate hyperuricemia. We speculated that the digestive peptides either generated by the gut flora or by the host digestive system might contribute to the gut microbiota reshaping. Specifically, the study implied that gut microbiota contains many unexplored targets with different therapeutic potentials. If a drug target is developed based on the gut microbiota, it will circumvent the unwanted effects of direct human target utilization. This drug target development notion change will revolutionize the traditional disease-treating paradigm.
Publish Date	2024-11-13 10:10
Citation	<p>Han S, Li RH, Gao P. Gut microbiota participates and remodels host metabolism: From treating patients to treating their gut flora. <i>World J Gastroenterol</i> 2024; 30(45): 4839-4843</p>
URL	https://www.wjgnet.com/1007-9327/full/v30/i45/4839.htm
DOI	https://dx.doi.org/10.3748/wjg.v30.i45.4839

Full Article (PDF)	WJG-30-4839-with-cover.pdf
Manuscript File	99727_Auto_Edited_060956.docx
Answering Reviewers	99727-answering-reviewers.pdf
Audio Core Tip	99727-audio.m4a
Conflict-of-Interest Disclosure Form	99727-conflict-of-interest-statement.pdf
Copyright License Agreement	99727-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate	99727-non-native-speakers.pdf
Peer-review Report	99727-peer-reviews.pdf
Scientific Misconduct Check	99727-scientific-misconduct-check.png
Scientific Editor Work List	99727-scientific-editor-work-list.pdf
CrossCheck Report	99727-crosscheck-report.pdf