Publication Name	World Journal of Diabetes
Manuscript ID	99745
Country	China

Received	2024-08-07 00:07
Peer-Review Started	2024-08-08 01:07
To Make the First Decision
Return for Revision	2024-09-17 20:48
Revised	2024-09-21 14:52
Second Decision	2024-10-15 08:00
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-10-24 08:16
Articles in Press	2024-10-24 08:16
Publication Fee Transferred	2024-10-28 11:33
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-11-06 02:40
Publish the Manuscript Online	2024-11-30 03:48

ISSN	1948-9358 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Medicine, Research & Experimental
Manuscript Type	Basic Study
Article Title	Betaine combined with traditional Chinese medicine ointment to treat skin wounds in microbially infected diabetic mice
Manuscript Source	Unsolicited Manuscript
All Author List	Wen-Yan Xu, Yuan-Yuan Dai, Shi-Xian Yang, Hao Chen, Yan-Qiang Huang, Pei-Pei Luo and Zhong-Heng Wei
ORCID	Author(s) ORCID Number Wen-Yan Xu http://orcid.org/0009-0006-4786-4537 Yuan-Yuan Dai http://orcid.org/0009-0001-8937-1873 Shi-Xian Yang http://orcid.org/0009-0001-4377-4562 Hao Chen http://orcid.org/0000-0003-0760-3552 Yan-Qiang Huang http://orcid.org/0000-0002-0867-0178 Pei-Pei Luo http://orcid.org/0000-0002-8965-1998 Zhong-Heng Wei http://orcid.org/0009-0006-8006-5112
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 32360035 and 32060018 Guangxi Science and Technology Major Projects 2023AA20009
Corresponding Author	Zhong-Heng Wei, Guangxi Clinical Medical Research Center for Hepatobiliary Diseases, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise 533000, Guangxi Zhuang Autonomous Region, China. 01118@ymun.edu.cn
Key Words	Betaine ointment; Staphylococcus aureus; Drug resistance; Skin infection; Diabetes mellitus
Core Tip	Antibiotic ointments are commonly used to treat wounds in diabetic patients, but the antibacterial spectrum is narrow, resistance occurs easily or does not effectively inhibit drug-resistant bacteria, and wound healing is slow. The focus of this study was to determine whether some natural Chinese medicines and betaine could enhance the antimicrobial, anti-inflammatory, anti-apoptotic and accelerated wound healing effects of the ointment. Therefore, we generated a novel betaine ointment (BO) and evaluated its effects and safety. We found that BO could reduce the colonization of pathogens, inflammation and apoptosis and contribute to the proliferation of granulomas, which has good prospects for application.
Publish Date	2024-11-30 03:48
Citation	<p>Xu WY, Dai YY, Yang SX, Chen H, Huang YQ, Luo PP, Wei ZH. Betaine combined with traditional Chinese medicine ointment to treat skin wounds in microbially infected diabetic mice. <i>World J Diabetes</i> 2025; 16(1): 99745</p>
URL	https://www.wjgnet.com/1948-9358/full/v16/i1/99745.htm
DOI	https://dx.doi.org/10.4239/wjd.v16.i1.99745

Full Article (PDF)	WJD-16-99745-with-cover.pdf
The ARRIVE Guidelines	99745-The-ARRIVE-Guidelines.pdf
Manuscript File	99745_Auto_Edited_010348.docx
Answering Reviewers	99745-answering-reviewers.pdf
Audio Core Tip	99745-audio.aac
Biostatistics Review Certificate	99745-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form	99745-conflict-of-interest-statement.pdf
Copyright License Agreement	99745-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	99745-foundation-statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	99745-institutional-animal-care-and-use-committee-statement.pdf
Non-Native Speakers of English Editing Certificate	99745-non-native-speakers.pdf
Peer-review Report	99745-peer-reviews.pdf
Journal Editor-in-Chief Review Report	99745-journal-editor-in-chief.pdf
Scientific Misconduct Check	99745-scientific-misconduct-check.png
Scientific Editor Work List	99745-scientific-editor-work-list.pdf
CrossCheck Report	99745-crosscheck-report.pdf