Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	99752
Country	China

Received	2024-07-29 14:19
Peer-Review Started	2024-07-29 14:19
To Make the First Decision
Return for Revision	2024-09-10 02:38
Revised	2024-09-23 11:51
Second Decision	2024-10-28 02:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-10-28 06:31
Articles in Press	2024-10-28 06:31
Publication Fee Transferred	2024-10-31 14:40
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-11-06 08:10
Publish the Manuscript Online	2024-12-27 13:37

ISSN	1948-9366 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Infectious Diseases
Manuscript Type	Case Report
Article Title	Five-year complete remission of super-giant hepatocellular carcinoma with hepatectomy followed by sorafenib plus camrelizumab: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Xiao-Qin Zheng, Li-Bo Sun, Wen-Jie Jin, Hui Liu, Wen-Yan Song, Hui Xu, Ju-Shan Wu, Xiao-Jun Wang, Chun-Yan Gou and Hui-Guo Ding
ORCID	Author(s) ORCID Number Wen-Yan Song http://orcid.org/0000-0002-4563-6243 Ju-Shan Wu http://orcid.org/0000-0001-5514-7243 Xiao-Jun Wang http://orcid.org/0000-0003-2432-511X Hui-Guo Ding http://orcid.org/0000-0002-8716-4926
Funding Agency and Grant Number
Corresponding Author	Hui-Guo Ding, Department of Gastroenterology and Hepatology, Beijing Youan Hospital, Capital Medical University, No. 8 Xitoutiao, Youanmenwai, Fengtai District, Beijing 100069, China. dinghuiguo@ccmu.edu.cn
Key Words	Hepatectomy; Sorafenib; Camrelizumab; Super-giant hepatocellular carcinoma; Complete remission; Case report
Core Tip	Cirrhotic patients with super-giant hepatocellular carcinoma (HCC), accompanied by portal vein invasion, generally have a poor prognosis. We report a patient with super-giant HCC and portal vein invasion, who underwent hepatectomy followed by sorafenib plus camrelizumab, resulting in complete remission for 5 years. However, two critical issues are raised: One is how to screen and manage portal hypertension in HCC, and the other is related to the optimal treatment duration of tyrosine kinase inhibitors and immune checkpoint inhibitors in HCC patients who achieve complete remission. Further research is needed to address these challenges.
Publish Date	2024-12-27 13:37
Citation	<p>Zheng XQ, Sun LB, Jin WJ, Liu H, Song WY, Xu H, Wu JS, Wang XJ, Gou CY, Ding HG. Five-year complete remission of super-giant hepatocellular carcinoma with hepatectomy followed by sorafenib plus camrelizumab: A case report. <i>World J Gastrointest Surg</i> 2025; 17(1): 99752</p>
URL	https://www.wjgnet.com/1948-9366/full/v17/i1/99752.htm
DOI	https://dx.doi.org/10.4240/wjgs.v17.i1.99752

Full Article (PDF)	WJGS-17-99752-with-cover.pdf
CARE Checklist–2016	99752-CARE-Checklist-2016.pdf
Manuscript File	99752_Auto_Edited_013405.docx
Answering Reviewers	99752-answering-reviewers.pdf
Audio Core Tip	99752-audio.m4a
Conflict-of-Interest Disclosure Form	99752-conflict-of-interest-statement.pdf
Copyright License Agreement	99752-copyright-assignment.pdf
Signed Consent for Treatment Form(s) or Document(s)	99752-informed-consent-statement.pdf
Non-Native Speakers of English Editing Certificate	99752-non-native-speakers.pdf
Peer-review Report	99752-peer-reviews.pdf
Scientific Misconduct Check	99752-scientific-misconduct-check.png
Scientific Editor Work List	99752-scientific-editor-work-list.pdf
CrossCheck Report	99752-crosscheck-report.pdf