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1/7/2015 11:06:00 AM | Browse: 559 | Download: 692
Publication Name World Journal of Gastroenterology
Manuscript ID 9980
Country of Manuscript Source Japan
2014-03-07 13:49
Peer-Review Started
2014-03-07 14:04
To Make the First Decision
2014-04-02 19:25
Return for Revision
2014-04-14 08:16
2014-05-11 20:24
Second Decision
2014-09-19 08:50
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-09-19 09:23
Articles in Press
2014-09-19 10:23
Publication Fee Transferred
Edit the Manuscript by Language Editor
2014-11-12 17:25
Typeset the Manuscript
2014-12-19 11:05
Publish the Manuscript Online
2015-01-07 11:07
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Autobiography
Article Title Beneficial effect of an omega-6 PUFA-rich diet in non-steroidal anti-inflammatory drug-induced mucosal damage in the murine small intestinez
Manuscript Source Unsolicited Manuscript
All Author List Toshihide Ueda, Ryota Hokari, Masaaki Higashiyama, Yuichi Yasutake, Koji Maruta, Chie Kurihara, Kengo Tomita, Shunsuke Komoto, Yoshikiyo Okada, Chikako Watanabe, Shingo Usui, Shigeaki Nagao and Soichiro Miura
Funding Agency and Grant Number
Funding Agency Grant Number
National Defense Medical College
Health and Labour Sciences Research Grants
Research for the similarity and difference in epidemiology, pathophysiology, diagnosis and treatment of rare intestinal refractory diseases
Smoking Research Foundation
Corresponding author Ryota Hokari, MD, Professor, Department of Internal Medicine, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan. ryota@ndmc.ac.jp
Keywords Non-steroidal anti-inflammatory drugs; Small intestine; Ulcer; Dietary fat; Adhesion molecules
Core Tip Non-steroidal anti-inflammatory drugs (NSAIDs) frequently induce mucosal damage in the gastrointestinal tract. The recently developed techniques of capsule enteroscopy and double balloon enteroscopy have shown that NSAIDs cause ulcers in the small intestine (68%) more frequently than previously thought. Although proton pump inhibitors are key drugs for NSAIDs-induced gastropathy, proton pump inhibitors have no effect on NSAIDs-induced intestinal lesions and no drugs are currently available for the prevention and treatment of NSAIDs-induced intestinal lesions. In the present study, we showed the beneficial effect of an omega-6 PUFA-rich diet in NSAID-induced mucosal damage in the murine small intestine. This is a completely novel finding and is important not only in the clinical field, but also in preventive medicine.
Publish Date 2015-01-07 11:07
Citation Ueda T, Hokari R, Higashiyama M, Yasutake Y, Maruta K, Kurihara C, Tomita K, Komoto S, Okada Y, Watanabe C, Usui S, Nagao S, Miura S. Beneficial effect of an omega-6 PUFA-rich diet in non-steroidal anti-inflammatory drug-induced mucosal damage in the murine small intestine. World J Gastroenterol 2015; 21(1): 177-186
Url http://www.wjgnet.com/1007-9327/full/v21/i1/177.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i1.177
Full Article (PDF) WJG-21-1.pdf
Full Article (Word) WJG-21-1.doc
Manuscript File 9980-Review.doc
Answering Reviewers 9980-Answering reviewers.pdf
Copyright License Agreement 9980-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 9980-Language certificate.pdf
Peer-review Report 9980-Peer review.pdf
Scientific Misconduct Check 9980-CorssCheck.jpg
Scientific Editor Work List 9980-Scientific editor work list.pdf