| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Overexpression pattern, function, and clinical value of proteasome 26S subunit non-ATPase 6 in hepatocellular carcinoma
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Sheng-Sheng Zhou, Yu-Ping Ye, Yi Chen, Da-Tong Zeng, Guang-Cai Zheng, Rong-Quan He, Bang-Teng Chi, Lei Wang, Qian Lin, Qin-Yan Su, Yi-Wu Dang, Gang Chen and Jia-Liang Wei |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82160762 |
| Guangxi Zhuang Autonomous Region Administration of Traditional Chinese Medicine Scientific Research Project |
GXZYA20230267 |
| China Undergraduate Innovation and Entrepreneurship Training Program |
S202410598060X |
| China Undergraduate Innovation and Entrepreneurship Training Program |
X202410598360 |
| Future Academic Star of Guangxi Medical University |
WLXSZX24074 |
|
| Corresponding Author |
Gang Chen, PhD, Professor, Department of Pathology, The First Affiliated Hospital of Guangxi Medical University, No. 22 Shuangyong Road, Nanning 530021, Guangxi Zhuang Autonomous Region, China. chengang@gxmu.edu.cn |
| Key Words |
Hepatocellular carcinoma; Proteasome 26S subunit non-ATPase 6; Clustered regularly interspaced short palindromic repeats; Ribosome biogenesis; RNA splicing |
| Core Tip |
This study integrated 8339 hepatocellular carcinoma (HCC) tissue mRNA expression profiles from 41 platforms, 383 pairs of hepatocellular tissue samples from inhouse immunohistochemistry experiments, and HCC cell lines using the clustered regularly interspaced short palindromic repeats system for proteasome 26s subunit non-ATPase 6 (PSMD6) knockout data to evaluate the abnormal expression pattern and clinical significance of PSMD6 in HCC tissues. This study was the first to discover that PSMD6 was overexpressed in HCC tissues. The promotion of PSMD6 in HCC progression is closely related to ribosome biogenesis and RNA splicing, suggesting that PSMD6 may enhance the proliferation of HCC cells. |
| Publish Date |
2024-12-11 10:19 |
| Citation |
<p>Zhou SS, Ye YP, Chen Y, Zeng DT, Zheng GC, He RQ, Chi BT, Wang L, Lin Q, Su QY, Dang YW, Chen G, Wei JL. Overexpression pattern, function, and clinical value of proteasome 26S subunit non-ATPase 6 in hepatocellular carcinoma. <i>World J Clin Oncol</i> 2025; 16(2): 99839</p> |
| URL |
https://www.wjgnet.com/2218-4333/full/v16/i2/99839.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v16.i2.99839 |
