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8/26/2014 5:16:00 PM | Browse: 901 | Download: 628
Publication Name World Journal of Gastroenterology
Manuscript ID 9984
Country/Territory China
Received
2014-03-07 11:37
Peer-Review Started
2014-03-07 11:48
To Make the First Decision
2014-03-12 12:31
Return for Revision
2014-03-13 08:40
Revised
Second Decision
2014-05-14 09:07
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-05-14 09:45
Articles in Press
2014-05-23 10:41
Publication Fee Transferred
Edit the Manuscript by Language Editor
2014-05-19 23:23
Typeset the Manuscript
2014-05-23 14:14
Publish the Manuscript Online
2014-05-28 11:45
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Retrospective Study
Article Title LncRNAs expression signatures of hepatocellular carcinoma revealed by microarray
Manuscript Source Unsolicited Manuscript
All Author List Wu-Tao Liu, Xin Lu, Guang-Hua Tang, Jin-Jun Ren, Wen-Jun Liao, Peng-Lei Ge and Jie-Fu Huang
Funding Agency and Grant Number
Funding Agency Grant Number
China Medical Board of New York 11-045
National Key Technology Research and Development Program of China BAI06B01
Corresponding Author Xin Lu, MD, Professor of Surgery, Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No.1 Shuaifuyuan, Beijing 100730, China. luxinln@gmail.com
Key Words Long non-coding RNA; Hepatocellular carcinoma; MALAT1; Expression signature; Microarray
Core Tip Long non-coding RNAs (lncRNAs) possess prominent and diverse regulatory functions in cancer processes. In this study, the expression profiles of lncRNAs in hepatocellular carcinoma (HCC) were analyzed using a microarray-based method. One hundred and seventy-one lncRNAs were significantly downregulated and 488 were upregulated in HCC tissues. Validation was performed in 29 subjects with HCC using quantitative real-time polymerase chain reaction and the expressions of four lncRNAs were significantly downregulated in HCC, whereas the expression of lncRNA MALAT1 showed no significant difference. The same result was obtained in a subset of patients with hepatitis B virus-related HCC.
Publish Date 2014-05-28 11:45
Citation Liu WT, Lu X, Tang GH, Ren JJ, Liao WJ, Ge PL, Huang JF. LncRNAs expression signatures of hepatocellular carcinoma revealed by microarray. World J Gastroenterol 2014; 20(20): 6314-6321
URL http://www.wjgnet.com/1007-9327/full/v20/i20/6314.htm
DOI http://dx.doi.org/10.3748/wjg.v20.i20.6314
Full Article (PDF) WJG-20-6314.pdf
Full Article (Word) WJG-20-6314.doc
Manuscript File 9984-Review.doc
Answering Reviewers 9984-Answering reviewers.pdf
Copyright License Agreement 9984-Copyright assignment.pdf
Peer-review Report 9984-Peer review(s).pdf
Scientific Editor Work List 9984-Scientific editor work list.pdf