Publication Name	World Journal of Gastroenterology
Manuscript ID	99845
Country	United States

Received	2024-07-31 16:10
Peer-Review Started	2024-07-31 16:10
To Make the First Decision
Return for Revision	2024-09-07 16:11
Revised	2024-09-10 20:05
Second Decision	2024-09-18 02:47
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-09-18 04:58
Articles in Press	2024-09-18 04:58
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-09-20 00:48
Publish the Manuscript Online	2024-09-29 09:24

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Letter to the Editor
Article Title	Anti-tumor efficacy of Calculus bovis: Suppressing liver cancer by targeting tumor-associated macrophages
Manuscript Source	Invited Manuscript
All Author List	Ishita Kathuria and Bhupesh Singla
ORCID	Author(s) ORCID Number Bhupesh Singla http://orcid.org/0000-0003-2752-6849
Funding Agency and Grant Number	Funding Agency Grant Number National Institutes of Health grants No. K99HL146954 National Institutes of Health grants No. R00HL146954 UTHSC College of Pharmacy Research Seed Grant award No. 2023
Corresponding Author	Bhupesh Singla, MSc, PhD, Assistant Professor, Department of Pharmaceutical Sciences, The University of Tennessee Health Science Center, 881 Madison Ave, Room 446, Memphis, TN 38103, United States. bsingla@uthsc.edu
Key Words	Calculus bovis; Liver cancer; M2-like tumor associated macrophages; Wnt/β-catenin pathway; Tumor environment
Core Tip	Calculus bovis, a traditional animal drug used in China, has been recognized for its therapeutic effects across various organ systems, including the central nervous, cardiovascular, respiratory, and digestive systems. Recent studies have also suggested its anti-tumor potential. While previous studies have explored the mechanisms of action of its active compounds, this study provides novel insights into its anti-tumor potential using a liver cancer xenograft model. M2 macrophages are associated with tumor progression because they promote tumor growth, angiogenesis, and metastasis while inhibiting effective anti-tumor immune responses. This study, for the first time, demonstrates that Calculus bovis modulates the tumor environment by governing M2-tumor-associated macrophages in a Wnt pathway-dependent manner, thereby suppressing tumor growth.
Publish Date	2024-09-29 09:24
Citation	<p>Kathuria I, Singla B. Anti-tumor efficacy of Calculus bovis: Suppressing liver cancer by targeting tumor-associated macrophages. <i>World J Gastroenterol</i> 2024; 30(38): 4249-4253</p>
URL	https://www.wjgnet.com/1007-9327/full/v30/i38/4249.htm
DOI	https://dx.doi.org/10.3748/wjg.v30.i38.4249

Full Article (PDF)	WJG-30-4249-with-cover.pdf
Manuscript File	99845_Auto_Edited_012410.docx
Answering Reviewers	99845-answering-reviewers.pdf
Audio Core Tip	99845-audio.mp3
Conflict-of-Interest Disclosure Form	99845-conflict-of-interest-statement.pdf
Copyright License Agreement	99845-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	99845-foundation-statement.pdf
Peer-review Report	99845-peer-reviews.pdf
Scientific Misconduct Check	99845-scientific-misconduct-check.png
Scientific Editor Work List	99845-scientific-editor-work-list.pdf
CrossCheck Report	99845-crosscheck-report.png
CrossCheck Report	99845-crosscheck-report.pdf