Publication Name	World Journal of Immunology
Manuscript ID	9988
Country	Japan

Received	2014-03-07 14:20
Peer-Review Started	2014-03-10 09:11
To Make the First Decision	2014-04-04 16:02
Return for Revision	2014-04-10 23:08
Revised	2014-04-19 14:34
Second Decision	2014-06-16 13:59
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-06-16 14:09
Articles in Press	2014-06-16 14:45
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-07-21 20:29
Publish the Manuscript Online	2014-07-27 18:55

ISSN	2219-2824 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Virology
Manuscript Type	Review
Article Title	Role of host immune responses in sequence variability of HIV-1 Vpu
Manuscript Source	Invited Manuscript
All Author List	Zafrul Hasan, Doreen Kamori and Takamasa Ueno
Funding Agency and Grant Number	Funding Agency Grant Number Ministry of Education, Science, Sports, and Culture (MEXT) of Japan Ministry of Health, Labor, and Welfare of Japan Scholarship for the International Priority Graduate Programs (to Hasan Z and Kamori D) Advanced Graduate Courses for International Students (Doctoral Course), MEXT, Japan (to Hasan Z and Kamori D)
Corresponding Author	Takamasa Ueno, PhD, Center for AIDS Research, Kumamoto University, 2-2-1 Honjo, Kumamoto 860-0811, Japan. uenotaka@kumamoto-u.ac.jp
Key Words	Human immunodeficiency virus type 1; Vpu; Sequence variability; Immune responses; HLA class I
Core Tip	Viral protein U (Vpu) is a highly polymorphic human immunodeficiency virus type 1 (HIV-1) accessory protein; however factors that are attributable to Vpu sequence variability are not well defined. In this review we have focused on the immune responses both innate (natural killer cells) and adaptive (cellular and humoral) immunity that are directed towards HIV-1 Vpu and we also show the interaction between Vpu and host cellular factors. We also highlight evidence that suggests interaction between the host immune responses and Vpu may contribute to Vpu sequence variability. Finally we have summarized the current knowledge on HIV-1 Vpu functions including Vpu evasion activities from the host immune surveillance.
Publish Date	2014-07-27 18:55
Citation	Hasan Z, Kamori D, Ueno T. Role of host immune responses in sequence variability of HIV-1 Vpu. World J Immunol 2014; 4(2): 107-115
URL	http://www.wjgnet.com/2219-2824/full/v4/i2/107.htm
DOI	http://dx.doi.org/10.5411/wji.v4.i2.107

Full Article (PDF)	WJI-4-107.pdf
Full Article (Word)	WJI-4-107.doc
Manuscript File	9988-Review.doc
Answering Reviewers	9988-Answering reviewers.pdf
Copyright License Agreement	9988-Copyright assignment.pdf
Peer-review Report	9988-Peer review(s).pdf
Scientific Misconduct Check	9988-CrossCheck.jpg
Scientific Editor Work List	9988-Scientific editor work list.pdf