| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Basic Study |
| Article Title |
Extramural venous invasion in gastric cancer: 9.4T magnetic resonance imaging assessment and circular RNA functional analysis
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Cai-Zhen Feng, Xin-Yi Gou, Yi-Qun Liu, Yu-Wei Xin, Yin-Li Zhang, Hui-Min Zhao, Sheng-Cai Wei, Nan Hong, Yi Wang and Jin Cheng |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81901819 |
| Beijing Natural Science Foundation |
7232187 |
| Peking University People’s Hospital Scientific Research Development Funds |
RDX2024-08 |
|
| Corresponding Author |
Jin Cheng, Associate Professor, MD, Department of Radiology, Peking University People’s Hospital, No. 11 Xizhimen South Street, Xicheng District, Beijing 100044, China. chengjinpkuph@outlook.com |
| Key Words |
Gastric cancer; Circular RNA; Extramural venous invasion; Orthotopic mouse model; Magnetic resonance imaging; Pathology; Radiogenomics |
| Core Tip |
This study demonstrates that extramural venous invasion (EMVI), a risk factor for distant metastasis in gastric cancer (GC), can be accurately detected using 9.4T magnetic resonance imaging in orthotopic GC mouse models, with histopathological confirmation. The expression of hsa_circ_0097977, a circular RNA, was found to regulate EMVI, and its knockdown reduced tumor cell invasion and promoted apoptosis, suggesting its potential as a therapeutic target in GC. These findings highlight the clinical relevance of EMVI detection and the role of hsa_circ_0097977 in GC progression. |
| Publish Date |
2025-04-11 02:19 |
| Citation |
Feng CZ, Gou XY, Liu YQ, Xin YW, Zhang YL, Zhao HM, Wei SC, Hong N, Wang Y, Cheng J. Extramural venous invasion in gastric cancer: 9.4T magnetic resonance imaging assessment and circular RNA functional analysis. World J Gastroenterol 2025; 31(14): 99897 |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i14/99897.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i14.99897 |
