Publication Name	World Journal of Hepatology
Manuscript ID	99899
Country	Japan

Received	2024-08-02 09:12
Peer-Review Started	2024-08-02 09:12
To Make the First Decision
Return for Revision	2024-09-18 03:28
Revised	2024-09-21 14:30
Second Decision	2024-10-09 02:39
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-10-09 08:11
Articles in Press	2024-10-09 08:11
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-11-28 08:35
Publish the Manuscript Online	2025-04-25 08:22

ISSN	1948-5182 (online)
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Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Cholestasis in hepatitis E virus infection
Manuscript Source	Invited Manuscript
All Author List	Tatsuo Kanda, Reina Sasaki-Tanaka, Takeshi Yokoo, Kazunao Hayashi, Hiroteru Kamimura, Atsunori Tsuchiya and Shuji Terai
ORCID	Author(s) ORCID Number Tatsuo Kanda http://orcid.org/0009-0000-8135-342X Reina Sasaki-Tanaka http://orcid.org/0000-0003-2681-0776 Takeshi Yokoo http://orcid.org/0000-0001-7138-1785 Kazunao Hayashi http://orcid.org/0000-0003-3764-3598 Hiroteru Kamimura http://orcid.org/0000-0002-9135-3092 Atsunori Tsuchiya http://orcid.org/0000-0002-9279-5917 Shuji Terai http://orcid.org/0000-0002-5439-635X
Funding Agency and Grant Number	Funding Agency Grant Number Japan Agency for Medical Research and Development (AMED) JP24fk0210132 JSPS KAKENHI (to Dr. Sasaki-Tanaka R) JP23K15055
Corresponding Author	Tatsuo Kanda, MD, PhD, Professor, Department of Gastroenterology and Hepatology, Uonuma Institute of Community Medicine, Niigata University Medical and Dental Hospital, 4132 Urasa, Minamiuonuma 949-7302, Niigata, Japan. kandatatsuo@gmail.com
Key Words	Genomic mutations; Cholestasis; Farnesoid X receptor; Hepatitis E virus; Jaundice
Core Tip	Hepatitis E virus (HEV) infection triggers severe jaundice and prolonged cholestasis in patients with genetic variants in adenosine triphosphatase phospholipid transporting 8B1 (ATP8B1), adenosine triphosphate-binding cassette (ABC) protein B4, ABCB11, Myosin VB and/or farnesoid X receptor (FXR/NR1H4). Genomic mutations associated with hepatocanalicular transporter proteins occasionally cause cholestasis. HEV infection may trigger severe jaundice and prolonged cholestasis in patients with these genomic mutations.
Publish Date	2025-04-25 08:22
Citation	<p>Kanda T, Sasaki-Tanaka R, Yokoo T, Hayashi K, Kamimura H, Tsuchiya A, Terai S. Cholestasis in hepatitis E virus infection. <i>World J Hepatol</i> 2025; 17(4): 99899</p>
URL	https://www.wjgnet.com/1948-5182/full/v17/i4/99899.htm
DOI	https://dx.doi.org/10.4254/wjh.v17.i4.99899

Full Article (PDF)	WJH-17-99899-with-cover.pdf
Manuscript File	99899_Auto_Edited_035251.docx
Answering Reviewers	99899-answering-reviewers.pdf
Audio Core Tip	99899-audio.m4a
Conflict-of-Interest Disclosure Form	99899-conflict-of-interest-statement.pdf
Copyright License Agreement	99899-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	99899-foundation-statement.pdf
Non-Native Speakers of English Editing Certificate	99899-non-native-speakers.pdf
Peer-review Report	99899-peer-reviews.pdf
Scientific Misconduct Check	99899-scientific-misconduct-check.png
Scientific Editor Work List	99899-scientific-editor-work-list.pdf
CrossCheck Report	99899-crosscheck-report.pdf