Publication Name	World Journal of Immunology
Manuscript ID	9997
Country	Cuba

Received	2014-03-08 19:56
Peer-Review Started	2014-03-10 09:18
To Make the First Decision	2014-04-28 14:35
Return for Revision	2014-05-06 10:48
Revised	2014-05-27 21:22
Second Decision	2014-06-27 17:46
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-06-27 18:05
Articles in Press	2014-06-27 18:05
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-07-15 11:27
Publish the Manuscript Online	2014-07-27 18:55

ISSN	2219-2824 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Immunology
Manuscript Type	Review
Article Title	GM3-containing nanoparticles in immunosuppressed hosts: Effect on myeloid-derived suppressor cells
Manuscript Source	Invited Manuscript
All Author List	Audry Fernández, Liliana Oliver, Rydell Alvarez, Luis E Fernández and Circe Mesa
Funding Agency and Grant Number	Funding Agency Grant Number Center of Molecular Immunology
Corresponding Author	Circe Mesa, PhD, Director of Immunobiology Division, Center of Molecular Immunology, 216 St. and 15th Ave., Atabey, Playa, P.O. Box 16040, Havana 11600, Cuba. circe@cim.sld.cu
Key Words	Very small size proteoliposomes; Adjuvants; tumors; Myeloid-derived suppressor cells; Leukopenia; Chemotherapy
Core Tip	Very small size proteoliposomes (VSSP) is a nanoparticulated adjuvant being used in the formulation of several cancer vaccines that are currently in clinical trials. In this review we summarize the unique ability of VSSP to stimulate antigen-specific CD8+ T cell responses in tumor-bearing mice and in mice with chemotherapy-induced leukopenia, both immunosuppressive scenarios frequently found in cancer patients. As a possible mechanism of this efficacy, we have focused on the modulation of myeloid-derived suppressor cells (MDSCs) by these nanoparticles, in the context of the current knowledge about the interaction of cancer vaccine adjuvants with MDSCs.
Publish Date	2014-07-27 18:55
Citation	Fernández A, Oliver L, Alvarez R, Fernández LE, Mesa C. GM3-containing nanoparticles in immunosuppressed hosts: Effect on myeloid-derived suppressor cells. World J Immunol 2014; 4(2): 98-106
URL	http://www.wjgnet.com/2219-2824/full/v4/i2/98.htm
DOI	http://dx.doi.org/10.5411/wji.v4.i2.98

Full Article (PDF)	WJI-4-98.pdf
Full Article (Word)	WJI-4-98.doc
Manuscript File	9997-Review.doc
Answering Reviewers	9997-Answering reviewers.pdf
Copyright License Agreement	9997-Copyright assignment.pdf
Peer-review Report	9997-Peer revire(s).pdf
Scientific Misconduct Check	9997-CrossCheck.jpg
Scientific Editor Work List	9997-Scientific editor work list.pdf