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Articles Published Processes
12/20/2024 3:53:46 AM | Browse: 123 | Download: 599
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Received |
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2024-08-20 01:19 |
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Peer-Review Started |
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2024-08-04 13:51 |
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First Decision by Editorial Office Director |
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2024-09-15 20:42 |
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Return for Revision |
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2024-09-15 20:42 |
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Revised |
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2024-09-29 18:21 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2024-11-18 02:41 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2024-11-18 06:23 |
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Articles in Press |
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2024-11-18 06:23 |
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Edit the Manuscript by Language Editor |
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2024-11-25 21:31 |
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Typeset the Manuscript |
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2024-11-29 13:48 |
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Publish the Manuscript Online |
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2024-12-20 03:53 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Letter to the Editor |
| Article Title |
WNT/β-catenin-M2 macrophage interplay as a target for therapy against hepatocellular carcinoma: The role of Calculus bovis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Tryfonas Mpektsis, Anastasios Manolakis and Andreas Kapsoritakis |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Anastasios Manolakis, Assistant Professor, MD, PhD, Department of Gastroenterology, University Hospital of Larisa, Mezourlo, Larisa 41100, Greece. manolakis@uth.gr |
| Key Words |
Hepatocellular carcinoma; Calculus bovis; WNT/β-catenin pathway; Tumor-associated macrophages |
| Core Tip |
Activation of the WNT/β-catenin pathway plays an important role in hepatocellular carcinoma development and the modulation of the tumor microenvironment through M2 macrophage production. Calculus bovis (CB), a herb used in traditional Chinese medicine, exhibits liver anti-tumor properties: inhibition of the WNT/β-catenin pathway and subsequent decrease in M2 tumor-associated macrophages polarization. In all, the inhibition of WNT/β-catenin pathway emerges as a therapeutic target while the use of CB surfaces as potential medium to achieve this kind of modulation. CB, therefore, appears to be a lucrative candidate that can aid in the pharmacotherapy of hepatocellular carcinoma. |
| Publish Date |
2024-12-20 03:53 |
| Citation |
Mpektsis T, Manolakis A, Kapsoritakis A. WNT/β-catenin-M2 macrophage interplay as a target for therapy against hepatocellular carcinoma: The role of Calculus bovis. World J Gastroenterol 2025; 31(3): 99983
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| URL |
https://www.wjgnet.com/1007-9327/full/v31/i3/99983.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i3.99983 |
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