Publication Name	World Journal of Gastroenterology
Manuscript ID	99983
Country	Greece

Received	2024-08-20 01:19
Peer-Review Started	2024-08-04 13:51
To Make the First Decision
Return for Revision	2024-09-15 20:42
Revised	2024-09-29 18:21
Second Decision	2024-11-18 02:41
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-11-18 06:23
Articles in Press	2024-11-18 06:23
Publication Fee Transferred
Edit the Manuscript by Language Editor	2024-11-25 21:31
Typeset the Manuscript	2024-11-29 13:48
Publish the Manuscript Online	2024-12-20 03:53

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Letter to the Editor
Article Title	WNT/β-catenin-M2 macrophage interplay as a target for therapy against hepatocellular carcinoma: The role of Calculus bovis
Manuscript Source	Invited Manuscript
All Author List	Tryfonas Mpektsis, Anastasios Manolakis and Andreas Kapsoritakis
ORCID	Author(s) ORCID Number Anastasios Manolakis http://orcid.org/0000-0001-8661-6997
Funding Agency and Grant Number
Corresponding Author	Anastasios Manolakis, Assistant Professor, MD, PhD, Department of Gastroenterology, University Hospital of Larisa, Mezourlo, Larisa 41100, Greece. manolakis@uth.gr
Key Words	Hepatocellular carcinoma; Calculus bovis; WNT/β-catenin pathway; Tumor-associated macrophages
Core Tip	Activation of the WNT/β-catenin pathway plays an important role in hepatocellular carcinoma development and the modulation of the tumor microenvironment through M2 macrophage production.  Calculus bovis (CB), a herb used in traditional Chinese medicine, exhibits liver anti-tumor properties: inhibition of the WNT/β-catenin pathway and subsequent decrease in M2 tumor-associated macrophages polarization. In all, the inhibition of WNT/β-catenin pathway emerges as a therapeutic target while the use of CB surfaces as potential medium to achieve this kind of modulation. CB, therefore, appears to be a lucrative candidate that can aid in the pharmacotherapy of hepatocellular carcinoma.
Publish Date	2024-12-20 03:53
Citation	<p>Mpektsis T, Manolakis A, Kapsoritakis A. WNT/β-catenin-M2 macrophage interplay as a target for therapy against hepatocellular carcinoma: The role of Calculus bovis. <i>World J Gastroenterol</i> 2025; 31(3): 99983</p>
URL	https://www.wjgnet.com/1007-9327/full/v31/i3/99983.htm
DOI	https://dx.doi.org/10.3748/wjg.v31.i3.99983

Full Article (PDF)	WJG-31-99983-with-cover.pdf
Manuscript File	99983_Auto_Edited_112118.docx
Answering Reviewers	99983-answering-reviewers.pdf
Audio Core Tip	99983-audio.mp3
Conflict-of-Interest Disclosure Form	99983-conflict-of-interest-statement.pdf
Copyright License Agreement	99983-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate	99983-non-native-speakers.pdf
Peer-review Report	99983-peer-reviews.pdf
Scientific Misconduct Check	99983-scientific-misconduct-check.png
Scientific Editor Work List	99983-scientific-editor-work-list.pdf
CrossCheck Report	99983-crosscheck-report.pdf