| ISSN |
2220-3206 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Psychiatry |
| Manuscript Type |
Prospective Study |
| Article Title |
Cumulative effects of stress-sensitivity factors on depressive symptoms and suicide risk: A prospective study
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xue-Mei Qin, Meng-Qi Xu, Ya-Qi Qin, Fang-Zhou Shao, Mo-Han Ma, Wen-Wen Ou, Guan-Yi Lv, Qian-Qian Zhang, Wen-Tao Chen, Xiao-Tian Zhao, Ao-Qian Deng, Jin-Tao Xiong, Ling-Si Zeng, Yi-Lin Peng, Mei Huang, Shu-Yin Xu, Mei Liao, Li Zhang, Ling-Jiang Li, Yu-Meng Ju, Jin Liu, Bang-Shan Liu and Yan Zhang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Science and Technology Innovation 2030-Major Projects |
2021ZD0202000 |
| National Key Research and Development Program of China |
2019YFA0706200 |
| National Natural Science Foundation of China |
82371535 |
| Science and Technology Innovation Program of Hunan Province |
2023RC3083 |
| Fundamental Research Funds for the Central Universities of Central South University |
2023ZZTS0838 |
|
| Corresponding Author |
Bang-Shan Liu, MD, Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, No. 139 Renmin Middle Road, Changsha 410011, Hunan Province, China. bangshan.liu@csu.edu.cn |
| Key Words |
Major depressive disorder; Stress sensitivity; Depressive symptoms; Suicide risk; Cumulative effect |
| Core Tip |
How variously classified but related stress-sensitivity factors affected major depressive disorder (MDD) was unknown. This prospective study looked at the relationship between stress-sensitivity variables and MDD in a novel way. We found that in MDD patients with high-level stress-sensitivity components, baseline symptoms were worse; state factors, especially perceived stress, had a greater influence on depressive symptoms. Patients with high trait factors at follow-up performed worse, especially in trait anxiety- and neuroticism-influenced depressive symptoms and suicide risk, respectively. Screening for stress-sensitivity factors-especially trait ones-should be prioritized to improve disease prognosis. |
| Publish Date |
2025-01-14 08:49 |
| Citation |
<p>Qin XM, Xu MQ, Qin YQ, Shao FZ, Ma MH, Ou WW, Lv GY, Zhang QQ, Chen WT, Zhao XT, Deng AQ, Xiong JT, Zeng LS, Peng YL, Huang M, Xu SY, Liao M, Zhang L, Li LJ, Ju YM, Liu J, Liu BS, Zhang Y. Cumulative effects of stress-sensitivity factors on depressive symptoms and suicide risk: A prospective study. <i>World J Psychiatry</i> 2025; 15(2): 99996</p> |
| URL |
https://www.wjgnet.com/2220-3206/full/v15/i2/99996.htm |
| DOI |
https://dx.doi.org/10.5498/wjp.v15.i2.99996 |
