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10/1/2014 8:25:00 PM | Browse: 715 | Download: 644
Publication Name World Journal of Gastroenterology
Manuscript ID 10066
Country/Territory China
2014-03-11 14:32
Peer-Review Started
2014-03-11 14:42
To Make the First Decision
2014-03-27 21:09
Return for Revision
2014-03-31 10:13
2014-05-08 00:00
Second Decision
2014-05-26 21:35
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-05-26 21:58
Articles in Press
2014-05-26 22:10
Publication Fee Transferred
Edit the Manuscript by Language Editor
2014-05-30 15:41
Typeset the Manuscript
2014-09-12 15:51
Publish the Manuscript Online
2014-10-01 20:25
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Review
Article Title Role of Nrf2 in chronic liver disease
Manuscript Source Unsolicited Manuscript
All Author List Wei Tang, Yong-Fang Jiang, Murugavel Ponnusamy and Mamadou Diallo
Funding Agency and Grant Number
Funding Agency Grant Number
Scientific Research Projects from the Development and Reform Commission of Hunan Province, China 2011 (1318)
Scientific Research Projects from the Development and Reform Commission of Hunan Province, China 2012 (1493)
Scientific Research Projects from the Development and Reform Commission of Hunan Province, China 2013 (1132)
Corresponding Author Yong-Fang Jiang, MD, PhD, Liver Diseases Research Center, The Second Xiangya Hospital, Central South University, No.139 Middle Renmin Road, Changsha 410011, Hunan Province, China. jiangyongfang@hotmail.com
Key Words Nuclear erythroid 2-related factor 2; Chronic liver disease; Oxidative stress; Reactive oxygen species; Hepatic injury; Hepatic protection
Core Tip Chronic liver disease is associated with an imbalance, comprising increased reactive oxygen species and decreased net antioxidant activity. Oxidative stress plays an important role in the pathophysiological changes of liver diseases. Nuclear erythroid 2-related factor 2 (Nrf2) can activate cytoprotective genes and has a crucial role against oxidative stress to protect hepatic cells from oxidative damage. This article focuses on the activation the Nrf2-mediated antioxidant response, which prevents the progression of chronic liver disease and presents new treatment opportunities. Accordingly, integrative therapeutic strategies including Nrf2 activators have great potential as therapeutic agents against oxidative stress during chronic liver injuries.
Publish Date 2014-10-01 20:25
Citation Tang W, Jiang YF, Ponnusamy M, Diallo M. Role of Nrf2 in chronic liver disease. World J Gastroenterol 2014; 20(36): 13079-13087
URL http://www.wjgnet.com/1007-9327/full/v20/i36/13079.htm
DOI http://dx.doi.org/10.3748/wjg.v20.i36.13079
Full Article (PDF) WJG-20-13079.pdf
Full Article (Word) WJG-20-13079.doc
Manuscript File 10066-Review.doc
Answering Reviewers 10066-Answering reviewers.pdf
Copyright License Agreement 10066-Copyright Assignment.pdf
Peer-review Report 10066-Peer review.pdf
Scientific Misconduct Check 10066-CrossCheck.jpg
Scientific Editor Work List 10066-Scientific editor work list.pdf