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1/18/2015 4:09:00 PM | Browse: 1044 | Download: 1402
Publication Name World Journal of Gastroenterology
Manuscript ID 10201
Country/Territory China
Received
2014-03-19 09:53
Peer-Review Started
2014-03-19 13:07
To Make the First Decision
2014-04-28 13:57
Return for Revision
2014-05-05 10:36
Revised
2014-05-16 10:03
Second Decision
2014-07-16 12:55
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-07-16 13:06
Articles in Press
2014-07-16 17:56
Publication Fee Transferred
Edit the Manuscript by Language Editor
2014-07-27 20:36
Typeset the Manuscript
2014-12-27 20:28
Publish the Manuscript Online
2015-01-18 16:09
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Medicine, Research & Experimental
Manuscript Type Autobiography
Article Title E2F-1 overexpression inhibits human gastric cancer MGC-803 cell growth in vivo
Manuscript Source Unsolicited Manuscript
All Author List Wei-Yuan Wei, Lin-Hai Yan, Xiao-Tong Wang, Lei Li, Wen-Long Cao, Xiao-Shi Zhang, Ze-Xu Zhan, Han Yu, Yu-Bo Xie and Qiang Xiao
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 30860273
National Natural Science Foundation of China 81060201
Natural Science Foundation of Guangxi 2011GXNSFA018273
Natural Science Foundation of Guangxi 2013GXNSFAA019163
Key Health Science Project of Guangxi Key1298003-2-6
Corresponding Author Qiang Xiao, Professor, Department of Surgery, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning 530021, Guangxi Zhuang Autonomous Region, China. xiaoqiang20050@aliyun.com
Key Words E2F-1; Gastric cancer; Lentiviral vector; Mouse model
Core Tip Transcription factor E2F-1 is the prototypical E2F and is often implicated in DNA synthesis and repair, cell proliferation, and apoptosis. Our preliminary study revealed that high expression of E2F-1 significantly suppressed gastric cancer (GC) cell line progression in vitro. However, the role of E2F-1 overexpression in GC in vivo remains unknown. Our results showed that overexpression of E2F-1 significantly inhibited tumor growth and promoted tumor cell apoptosis in vivo. Survivin, Bcl-2, cyclin D1, S-phase kinase-associated protein 2 and c-Myc were upregulated, and Bax was downregulated by E2F-1. E2F-1 inhibits growth of GC cells via regulating multiple signaling pathways.
Publish Date 2015-01-18 16:09
Citation Wei WY, Yan LH, Wang XT, Li L, Cao WL, Zhang XS, Zhan ZX, Yu H, Xie YB, Xiao Q. E2F-1 overexpression inhibits human gastric cancer MGC-803 cell growth in vivo. World J Gastroenterol 2015; 21(2): 491-501
URL http://www.wjgnet.com/1007-9327/full/v21/i2/491.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i2.491
Full Article (PDF) WJG-21-491.pdf
Full Article (Word) WJG-21-491.doc
Manuscript File 10201-Review.doc
Answering Reviewers 10201-Answering reviewers.pdf
Copyright License Agreement 10201-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 10201-Language certificate.pdf
Peer-review Report 10201-Peer review.pdf
Scientific Misconduct Check 10201-CrossCheck.jpg
Scientific Editor Work List 10201-Scientific editor work list.pdf